Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle. Here, myosin II inhibition rescues rupture and partially rescues the DNA damage marker γH2AX, but an apparent block in cell cyc...

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Detalles Bibliográficos
Autores principales: Xia, Yuntao, Pfeifer, Charlotte R., Zhu, Kuangzheng, Irianto, Jerome, Liu, Dazhen, Pannell, Kalia, Chen, Emily J., Dooling, Lawrence J., Tobin, Michael P., Wang, Mai, Ivanovska, Irena L., Smith, Lucas R., Greenberg, Roger A., Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683732/
https://www.ncbi.nlm.nih.gov/pubmed/31239284
http://dx.doi.org/10.1083/jcb.201811100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683732/
https://www.ncbi.nlm.nih.gov/pubmed/31239284
http://dx.doi.org/10.1083/jcb.201811100

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