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Filamin A mediates isotropic distribution of applied force across the actin network

Cell sensing of externally applied mechanical strain through integrin-mediated adhesions is critical in development and physiology of muscle, lung, tendon, and arteries, among others. We examined the effects of strain on force transmission through the essential cytoskeletal linker talin. Using a flu...

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Detalles Bibliográficos
Autores principales: Kumar, Abhishek, Shutova, Maria S., Tanaka, Keiichiro, Iwamoto, Daniel V., Calderwood, David A., Svitkina, Tatyana M., Schwartz, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683746/
https://www.ncbi.nlm.nih.gov/pubmed/31315944
http://dx.doi.org/10.1083/jcb.201901086