Cargando…

High-resolution imaging reveals how the spindle midzone impacts chromosome movement

In the spindle midzone, microtubules from opposite half-spindles form bundles between segregating chromosomes. Microtubule bundles can either push or restrict chromosome movement during anaphase in different cellular contexts, but how these activities are achieved remains poorly understood. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pamula, Melissa C., Carlini, Lina, Forth, Scott, Verma, Priyanka, Suresh, Subbulakshmi, Legant, Wesley R., Khodjakov, Alexey, Betzig, Eric, Kapoor, Tarun M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683753/ https://www.ncbi.nlm.nih.gov/pubmed/31248912 http://dx.doi.org/10.1083/jcb.201904169

Ejemplares similares

Coupling of microtubule bundles isolates them from local disruptions to set the structural stability of the anaphase spindle
por: Carlini, Lina, et al.
Publicado: (2022)

Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly
por: Ibarlucea-Benitez, Itziar, et al.
Publicado: (2018)

Regulation of cell cycle by the anaphase spindle midzone
por: Murata-Hori, Maki, et al.
Publicado: (2004)

Self-Organization of Minimal Anaphase Spindle Midzone Bundles
por: Hannabuss, Jonathon, et al.
Publicado: (2019)

Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly
por: Lucena, Rafael, et al.
Publicado: (2015)

Air-drying of cells enables visualization of antiparallel microtubule overlaps in the spindle midzone
por: Ifuji, Aya, et al.
Publicado: (2018)

Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis
por: Khodjakov, Alexey, et al.
Publicado: (2003)

Direct kinetochore–spindle pole connections are not required for chromosome segregation
por: Sikirzhytski, Vitali, et al.
Publicado: (2014)

Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol
por: Mitchison, Timothy J., et al.
Publicado: (2013)

PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone
por: Mollinari, Cristiana, et al.
Publicado: (2002)

The kinesin-8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization
por: Rizk, Rania S., et al.
Publicado: (2014)

Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone
por: Thomas, Ezekiel C., et al.
Publicado: (2020)

Recruitment of Polo Kinase to the Spindle Midzone during Cytokinesis Requires the Feo/Klp3A Complex
por: D'Avino, Pier Paolo, et al.
Publicado: (2007)

The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix
por: Schuyler, Scott C., et al.
Publicado: (2003)

Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B
por: Lera-Ramirez, Manuel, et al.
Publicado: (2022)

Chromosome Fragments Possessing Only One Kinetochore Can Congress to the Spindle Equator
por: Khodjakov, Alexey, et al.
Publicado: (1997)

Role of spatial patterns and kinetochore architecture in spindle morphogenesis
por: Renda, Fioranna, et al.
Publicado: (2021)

The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos
por: Wang, Haifeng, et al.
Publicado: (2015)

Thirty years of search and capture: The complex simplicity of mitotic spindle assembly
por: Heald, Rebecca, et al.
Publicado: (2015)

Micromanipulation studies of chromosome movement. I. Chromosome-spindle attachment and the mechanical properties of chromosomal spindle fibers
Publicado: (1979)

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells
por: Burkard, Mark E., et al.
Publicado: (2009)

Development of PBC/SSc overlap syndrome in chronic GVHD patient: immunological implications in the presence of mitochondrial, nucleolar and spindle midzone autoantigens
por: Assandri, Roberto, et al.
Publicado: (2017)

Relative contributions of chromatin and kinetochores to mitotic spindle assembly
por: O'Connell, Christopher B., et al.
Publicado: (2009)

Metaphase Spindle Assembly
por: Kapoor, Tarun M.
Publicado: (2017)

Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis
por: Maiato, Helder, et al.
Publicado: (2004)

Cdc14-regulated midzone assembly controls anaphase B
por: Khmelinskii, Anton, et al.
Publicado: (2007)

Chromosome Movement in Mitosis Requires Microtubule Anchorage at Spindle Poles
por: Gordon, Michael B., et al.
Publicado: (2001)

Micromanipulation studies of chromosome movement. II. Birefringent chromosomal fibers and the mechanical attachment of chromosomes to the spindle
Publicado: (1979)

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles
por: Gaetz, Jedidiah, et al.
Publicado: (2004)

The Spindle Pole Bodies Facilitate Nuclear Envelope Division during Closed Mitosis in Fission Yeast
por: Zheng, Liling, et al.
Publicado: (2007)

Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix
por: Kapoor, Tarun M., et al.
Publicado: (2001)

Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth
por: David, Ana F., et al.
Publicado: (2019)

Anaphase A Chromosome Movement and Poleward Spindle Microtubule Flux Occur At Similar Rates in Xenopus Extract Spindles
por: Desai, Arshad, et al.
Publicado: (1998)

The mechanics of microtubule networks in cell division
por: Forth, Scott, et al.
Publicado: (2017)

Oscillatory movements of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle
Publicado: (1986)

The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes
por: O'Connell, Christopher B., et al.
Publicado: (2008)

Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?
por: Imhof, Simon, et al.
Publicado: (2016)

Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells
por: Kural, Comert, et al.
Publicado: (2015)

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis
por: Kotýnková, Kristýna, et al.
Publicado: (2016)

Distinguishing midzonal iris pigment epithelial cyst from adenoma and ciliary body melanoma
por: Mayro, Eileen L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_66hfctamjt7ts8srsjhcih0mgq