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Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda

The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfectio...

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Autores principales: Baluku, Joseph Baruch, Nassozi, Sylvia, Gyagenda, Brian, Namanda, Margret, Andia-Biraro, Irene, Worodria, William, Byakika-Kibwika, Pauline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683771/
https://www.ncbi.nlm.nih.gov/pubmed/31428162
http://dx.doi.org/10.1155/2019/3741294
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author Baluku, Joseph Baruch
Nassozi, Sylvia
Gyagenda, Brian
Namanda, Margret
Andia-Biraro, Irene
Worodria, William
Byakika-Kibwika, Pauline
author_facet Baluku, Joseph Baruch
Nassozi, Sylvia
Gyagenda, Brian
Namanda, Margret
Andia-Biraro, Irene
Worodria, William
Byakika-Kibwika, Pauline
author_sort Baluku, Joseph Baruch
collection PubMed
description The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted.
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spelling pubmed-66837712019-08-19 Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda Baluku, Joseph Baruch Nassozi, Sylvia Gyagenda, Brian Namanda, Margret Andia-Biraro, Irene Worodria, William Byakika-Kibwika, Pauline J Trop Med Research Article The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted. Hindawi 2019-07-25 /pmc/articles/PMC6683771/ /pubmed/31428162 http://dx.doi.org/10.1155/2019/3741294 Text en Copyright © 2019 Joseph Baruch Baluku et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Baluku, Joseph Baruch
Nassozi, Sylvia
Gyagenda, Brian
Namanda, Margret
Andia-Biraro, Irene
Worodria, William
Byakika-Kibwika, Pauline
Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
title Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
title_full Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
title_fullStr Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
title_full_unstemmed Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
title_short Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
title_sort prevalence of malaria and tb coinfection at a national tuberculosis treatment centre in uganda
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683771/
https://www.ncbi.nlm.nih.gov/pubmed/31428162
http://dx.doi.org/10.1155/2019/3741294
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