The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice

Myxoid liposarcoma is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. Here, we report the gen...

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Detalles Bibliográficos
Autores principales: Chen, Mark, Xu, Eric S., Leisenring, Nathan H., Cardona, Diana M., Luo, Lixia, Ma, Yan, Ventura, Andrea, Kirsch, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683777/
https://www.ncbi.nlm.nih.gov/pubmed/31427882
http://dx.doi.org/10.1155/2019/1340261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683777/
https://www.ncbi.nlm.nih.gov/pubmed/31427882
http://dx.doi.org/10.1155/2019/1340261

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