Defining Alcohol-Related Phenotypes in Humans: The Collaborative Study on the Genetics of Alcoholism

Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COGA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects an...

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Detalles Bibliográficos
Autores principales: Bierut, Laura Jean, Saccone, Nancy L., Rice, John P., Goate, Alison, Foroud, Tatiana, Edenberg, Howard, Almasy, Laura, Conneally, P. Michael, Crowe, Raymond, Hesselbrock, Victor, Li, T. K., Nurnberger, John, Porjesz, Bernice, Schuckit, Marc A., Tischfield, Jay, Begleiter, Henri, Reich, Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2002
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683836/
https://www.ncbi.nlm.nih.gov/pubmed/12875049
Descripción
Sumario:Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COGA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electrophysiological, and genetic analyses of the participants. These analyses have identified several traits, or phenotypes, that appear to be genetically determined, such as the presence of alcohol dependence, the level of response to alcohol, the presence of coexisting depression, or the maximum number of drinks a person consumes per occasion. Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further.

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