Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)

OBJECTIVE: This study aimed to investigate serum levels of the cystatin C (CysC)/creatinine (Cr) ratio and renal serum markers (CysC, Cr, urea, and uric acid [UA]) for different ages and by sex. We also aimed to establish pediatric reference intervals for the serum CysC/Cr ratio. METHODS: Serum samp...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Changjin, Wen, Jing, Xiang, Jialin, Ouyang, Xuhong, Yang, Yan, Lu, Wei, Wang, Jianwei, Huang, Jian, Min, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Clinical Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683897/
https://www.ncbi.nlm.nih.gov/pubmed/31187682
http://dx.doi.org/10.1177/0300060519855575
_version_ 1783442178518810624
author Liu, Changjin
Wen, Jing
Xiang, Jialin
Ouyang, Xuhong
Yang, Yan
Lu, Wei
Wang, Jianwei
Huang, Jian
Min, Xun
author_facet Liu, Changjin
Wen, Jing
Xiang, Jialin
Ouyang, Xuhong
Yang, Yan
Lu, Wei
Wang, Jianwei
Huang, Jian
Min, Xun
author_sort Liu, Changjin
collection PubMed
description OBJECTIVE: This study aimed to investigate serum levels of the cystatin C (CysC)/creatinine (Cr) ratio and renal serum markers (CysC, Cr, urea, and uric acid [UA]) for different ages and by sex. We also aimed to establish pediatric reference intervals for the serum CysC/Cr ratio. METHODS: Serum samples were collected from 4765 healthy children (0–18 years old). Serum markers of renal function were measured, and the CysC/Cr ratio of each participant was calculated and statistically analyzed. RESULTS: The renal marker CysC did not substantially change after 1 year old. Cr, urea, and UA levels generally increased with age. However, the serum CysC/Cr ratio steadily decreased with age. The CysC/Cr ratio showed significant differences in age among all age groups and varied with sex, except for in the 1 to 6-year-old groups. The overall serum CysC/Cr ratio in girls was higher than that in boys. CONCLUSION: Reference intervals of the serum CysC/Cr ratio in the pediatric population were established. These intervals need to be partitioned by age and sex.
format Online
Article
Text
id pubmed-6683897
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-66838972019-08-19 Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old) Liu, Changjin Wen, Jing Xiang, Jialin Ouyang, Xuhong Yang, Yan Lu, Wei Wang, Jianwei Huang, Jian Min, Xun J Int Med Res Clinical Research Reports OBJECTIVE: This study aimed to investigate serum levels of the cystatin C (CysC)/creatinine (Cr) ratio and renal serum markers (CysC, Cr, urea, and uric acid [UA]) for different ages and by sex. We also aimed to establish pediatric reference intervals for the serum CysC/Cr ratio. METHODS: Serum samples were collected from 4765 healthy children (0–18 years old). Serum markers of renal function were measured, and the CysC/Cr ratio of each participant was calculated and statistically analyzed. RESULTS: The renal marker CysC did not substantially change after 1 year old. Cr, urea, and UA levels generally increased with age. However, the serum CysC/Cr ratio steadily decreased with age. The CysC/Cr ratio showed significant differences in age among all age groups and varied with sex, except for in the 1 to 6-year-old groups. The overall serum CysC/Cr ratio in girls was higher than that in boys. CONCLUSION: Reference intervals of the serum CysC/Cr ratio in the pediatric population were established. These intervals need to be partitioned by age and sex. SAGE Publications 2019-06-12 2019-07 /pmc/articles/PMC6683897/ /pubmed/31187682 http://dx.doi.org/10.1177/0300060519855575 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Liu, Changjin
Wen, Jing
Xiang, Jialin
Ouyang, Xuhong
Yang, Yan
Lu, Wei
Wang, Jianwei
Huang, Jian
Min, Xun
Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)
title Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)
title_full Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)
title_fullStr Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)
title_full_unstemmed Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)
title_short Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)
title_sort age- and sex-specific reference intervals for the serum cystatin c/creatinine ratio in healthy children (0–18 years old)
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683897/
https://www.ncbi.nlm.nih.gov/pubmed/31187682
http://dx.doi.org/10.1177/0300060519855575
work_keys_str_mv AT liuchangjin ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT wenjing ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT xiangjialin ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT ouyangxuhong ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT yangyan ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT luwei ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT wangjianwei ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT huangjian ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold
AT minxun ageandsexspecificreferenceintervalsfortheserumcystatinccreatinineratioinhealthychildren018yearsold

Ejemplares similares