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Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage

OBJECTIVE: To evaluate the effect of thrombin (TM) injection via the cerebellomedullary cistern on cerebral vessels in rats with subarachnoid hemorrhage (SAH). METHODS: Eighteen rats were randomly divided into three groups. In the A1 group, physiological saline was injected via the cerebellomedullar...

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Autores principales: Li, Gang, Wang, Qingsong, Lin, Tingting, Liu, Chengye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683912/
https://www.ncbi.nlm.nih.gov/pubmed/31179838
http://dx.doi.org/10.1177/0300060519851353
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author Li, Gang
Wang, Qingsong
Lin, Tingting
Liu, Chengye
author_facet Li, Gang
Wang, Qingsong
Lin, Tingting
Liu, Chengye
author_sort Li, Gang
collection PubMed
description OBJECTIVE: To evaluate the effect of thrombin (TM) injection via the cerebellomedullary cistern on cerebral vessels in rats with subarachnoid hemorrhage (SAH). METHODS: Eighteen rats were randomly divided into three groups. In the A1 group, physiological saline was injected via the cerebellomedullary cistern; in the A2 group, 3 U of TM was injected into the subarachnoid space; and in the A3 group, SAH models were established and 3 U of TM was injected with the first injection of whole blood. Three days later, basilar artery specimens were collected for pathological examination. RESULTS: The basilar arterial lumen cross-sectional area was significantly smaller in the A2 versus the A1 group, and proteinase-activated receptor (PAR)-1 and tumor necrosis factor (TNF)-α average optical densities were significantly higher (all P < 0.05). Basilar arterial lumen cross-sectional areas were significantly smaller in the A3 than the A2 group and average TNF-α optical densities were significantly lower (both P < 0.05), while those of PAR-1 did not differ significantly. CONCLUSIONS: There was no significant difference in the extent of cerebral vasospasm between SAH and non-SAH model groups following TM injection into the subarachnoid space, so TM was considered to be an independent factor affecting cerebral vasospasm.
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spelling pubmed-66839122019-08-19 Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage Li, Gang Wang, Qingsong Lin, Tingting Liu, Chengye J Int Med Res Meta-Analysis and Systematic Reviews OBJECTIVE: To evaluate the effect of thrombin (TM) injection via the cerebellomedullary cistern on cerebral vessels in rats with subarachnoid hemorrhage (SAH). METHODS: Eighteen rats were randomly divided into three groups. In the A1 group, physiological saline was injected via the cerebellomedullary cistern; in the A2 group, 3 U of TM was injected into the subarachnoid space; and in the A3 group, SAH models were established and 3 U of TM was injected with the first injection of whole blood. Three days later, basilar artery specimens were collected for pathological examination. RESULTS: The basilar arterial lumen cross-sectional area was significantly smaller in the A2 versus the A1 group, and proteinase-activated receptor (PAR)-1 and tumor necrosis factor (TNF)-α average optical densities were significantly higher (all P < 0.05). Basilar arterial lumen cross-sectional areas were significantly smaller in the A3 than the A2 group and average TNF-α optical densities were significantly lower (both P < 0.05), while those of PAR-1 did not differ significantly. CONCLUSIONS: There was no significant difference in the extent of cerebral vasospasm between SAH and non-SAH model groups following TM injection into the subarachnoid space, so TM was considered to be an independent factor affecting cerebral vasospasm. SAGE Publications 2019-06-10 2019-07 /pmc/articles/PMC6683912/ /pubmed/31179838 http://dx.doi.org/10.1177/0300060519851353 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta-Analysis and Systematic Reviews
Li, Gang
Wang, Qingsong
Lin, Tingting
Liu, Chengye
Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
title Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
title_full Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
title_fullStr Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
title_full_unstemmed Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
title_short Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
title_sort effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage
topic Meta-Analysis and Systematic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683912/
https://www.ncbi.nlm.nih.gov/pubmed/31179838
http://dx.doi.org/10.1177/0300060519851353
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