Cargando…

IL-27 promotes the expansion of self-renewing CD8(+) T cells in persistent viral infection

Chronic infection and cancer are associated with suppressed T cell responses in the presence of cognate antigen. Recent work identified memory-like CXCR5(+) TCF1(+) CD8(+) T cells that sustain T cell responses during persistent infection and proliferate upon anti-PD1 treatment. Approaches to expand...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Zhe, Zak, Jaroslav, Pratumchai, Isaraphorn, Shaabani, Namir, Vartabedian, Vincent F., Nguyen, Nhan, Wu, Tuoqi, Xiao, Changchun, Teijaro, John R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683984/ https://www.ncbi.nlm.nih.gov/pubmed/31164392 http://dx.doi.org/10.1084/jem.20190173

Ejemplares similares

B cell–derived IL-27 promotes control of persistent LCMV infection
por: Pratumchai, Isaraphorn, et al.
Publicado: (2022)

IFNAR1 signaling in NK cells promotes persistent virus infection
por: Huang, Zhe, et al.
Publicado: (2021)

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells
por: Honke, Nadine, et al.
Publicado: (2017)

Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells
por: Honke, Nadine, et al.
Publicado: (2022)

Enforced viral replication, a mechanism for immune activation
por: Lang, Karl S, et al.
Publicado: (2014)

Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells
por: Edgar, Landon J., et al.
Publicado: (2021)

IL-15 promotes self-renewal of progenitor exhausted CD8 T cells during persistent antigenic stimulation
por: Lee, Junghwa, et al.
Publicado: (2023)

IL-21 promotes the expansion of CD27(+)CD28(+) tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
por: Santegoets, Saskia JAM, et al.
Publicado: (2013)

Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome
por: Han, Zhen, et al.
Publicado: (2021)

Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control
por: Duhan, Vikas, et al.
Publicado: (2016)

Type I interferons in viral control and immune regulation
por: Teijaro, John R
Publicado: (2016)

Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN‐I responses
por: Honke, Nadine, et al.
Publicado: (2015)

IL-4 Induced Innate CD8(+) T Cells Control Persistent Viral Infection
por: Lee, Ara, et al.
Publicado: (2015)

IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence
por: Wehrens, Ellen J., et al.
Publicado: (2018)

P16-27.Optimization of the expansion of antigen-specific CD8+ T-cells for use in a viral suppression assay
por: Herman, MM, et al.
Publicado: (2009)

Cytomegalovirus-Specific IL-10-Producing CD4(+) T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence
por: Clement, Mathew, et al.
Publicado: (2016)

The IL‐27/IL‐27R axis is altered in CD4(+) and CD8(+) T lymphocytes from multiple sclerosis patients
por: Clénet, Marie‐Laure, et al.
Publicado: (2021)

Usp18 Driven Enforced Viral Replication in Dendritic Cells Contributes to Break of Immunological Tolerance in Autoimmune Diabetes
por: Honke, Nadine, et al.
Publicado: (2013)

Multiple functions of USP18
por: Honke, Nadine, et al.
Publicado: (2016)

CD4(+) T cell help and innate-derived IL-27 induce Blimp-1 dependent IL-10 production by anti-viral CTL
por: Sun, Jie, et al.
Publicado: (2011)

IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection
por: Harker, James A., et al.
Publicado: (2023)

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
por: Zhao, Fangzhu, et al.
Publicado: (2022)

A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro
por: Eshetu, Amare, et al.
Publicado: (2021)

The IL-27 receptor regulates TIGIT on memory CD4(+) T cells during sepsis
por: Morrow, Kristen N., et al.
Publicado: (2021)

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology
por: Pyle, Chloe J., et al.
Publicado: (2017)

Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
por: Shen, Zhongliang, et al.
Publicado: (2017)

IL-27 Regulated CD4(+)IL-10(+) T Cells in Experimental Sjögren Syndrome
por: Qi, Jingjing, et al.
Publicado: (2020)

Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2
por: Zhou, Xiaojuan, et al.
Publicado: (2021)

Pathway to a land-neutral expansion of Brazilian renewable fuel production
por: Ramirez Camargo, Luis, et al.
Publicado: (2022)

Associations of IL-27 Polymorphisms and Serum IL-27p28 Levels With Osteosarcoma Risk
por: Tang, Yu-jin, et al.
Publicado: (2014)

Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity
por: Juarez, Ignacio, et al.
Publicado: (2022)

A soluble activator that favors the ex vivo expansion of CD8(+)CD27(+) T cells
por: Matus, Esther I., et al.
Publicado: (2020)

Synergy of IL-21 and IL-15 in regulating CD8(+) T cell expansion and function
por: Zeng, Rong, et al.
Publicado: (2005)

Elimination of chronic viral infection by blocking CD27 signaling
por: Matter, Matthias, et al.
Publicado: (2006)

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
por: Ruiz-Riol, M., et al.
Publicado: (2017)

Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges
por: Tang, Daolin, et al.
Publicado: (2021)

Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells
por: Charville, Gregory W., et al.
Publicado: (2015)

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection
por: Lee, Seung-Hwan, et al.
Publicado: (2009)

IL-12 supports in vitro self-renewal of LT HSC
Publicado: (2022)

Editorial: IL-27 in health and disease
por: Imamichi, Tomozumi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9voiri3kq8nlgoc7fjb2gqmqno