Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons

Rheumatoid arthritis–associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypers...

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Detalles Bibliográficos
Autores principales: Bersellini Farinotti, Alex, Wigerblad, Gustaf, Nascimento, Diana, Bas, Duygu B., Morado Urbina, Carlos, Nandakumar, Kutty Selva, Sandor, Katalin, Xu, Bingze, Abdelmoaty, Sally, Hunt, Matthew A., Ängeby Möller, Kristina, Baharpoor, Azar, Sinclair, Jon, Jardemark, Kent, Lanner, Johanna T., Khmaladze, Ia, Borm, Lars E., Zhang, Lu, Wermeling, Fredrik, Cragg, Mark S., Lengqvist, Johan, Chabot-Doré, Anne-Julie, Diatchenko, Luda, Belfer, Inna, Collin, Mattias, Kultima, Kim, Heyman, Birgitta, Jimenez-Andrade, Juan Miguel, Codeluppi, Simone, Holmdahl, Rikard, Svensson, Camilla I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683987/
https://www.ncbi.nlm.nih.gov/pubmed/31196979
http://dx.doi.org/10.1084/jem.20181657

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