Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

To define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial Erk2 knockout in adult Erk1(−/−) mice. This resulted in a rapid onset of hypertension, a decrease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5 wk. Immunostai...

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Detalles Bibliográficos
Autores principales: Ricard, Nicolas, Scott, Rizaldy P., Booth, Carmen J., Velazquez, Heino, Cilfone, Nicholas A., Baylon, Javier L., Gulcher, Jeffrey R., Quaggin, Susan E., Chittenden, Thomas W., Simons, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683988/
https://www.ncbi.nlm.nih.gov/pubmed/31196980
http://dx.doi.org/10.1084/jem.20182151

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