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The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology

The membrane-anchored CX3CL1 is best known to exert its signaling function through binding its receptor CX3CR1. This study demonstrates a novel function that CX3CL1 exerts. CX3CL1 is sequentially cleaved by α-, β-, and γ-secretase, and the released CX3CL1 intracellular domain (CX3CL1-ICD) would tran...

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Detalles Bibliográficos
Autores principales:	Fan, Qingyuan, Gayen, Manoshi, Singh, Neeraj, Gao, Fan, He, Wanxia, Hu, Xiangyou, Tsai, Li-Huei, Yan, Riqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683996/ https://www.ncbi.nlm.nih.gov/pubmed/31209068 http://dx.doi.org/10.1084/jem.20182238

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