No IL-18BP? Avoid HAV

Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results...

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Detalles Bibliográficos
Autor principal: Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684000/
https://www.ncbi.nlm.nih.gov/pubmed/31243052
http://dx.doi.org/10.1084/jem.20190841
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author Diamond, Michael S.
author_facet Diamond, Michael S.
author_sort Diamond, Michael S.
collection PubMed
description Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and uncontrolled killing of hepatocytes.
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spelling pubmed-66840002020-02-05 No IL-18BP? Avoid HAV Diamond, Michael S. J Exp Med News Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and uncontrolled killing of hepatocytes. Rockefeller University Press 2019-08-05 2019-06-26 /pmc/articles/PMC6684000/ /pubmed/31243052 http://dx.doi.org/10.1084/jem.20190841 Text en © 2019 Diamond http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Diamond, Michael S.
No IL-18BP? Avoid HAV
title No IL-18BP? Avoid HAV
title_full No IL-18BP? Avoid HAV
title_fullStr No IL-18BP? Avoid HAV
title_full_unstemmed No IL-18BP? Avoid HAV
title_short No IL-18BP? Avoid HAV
title_sort no il-18bp? avoid hav
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684000/
https://www.ncbi.nlm.nih.gov/pubmed/31243052
http://dx.doi.org/10.1084/jem.20190841
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