Plasma ApoE elevations are associated with NAFLD: The PREVEND Study

Non-alcoholic fatty liver disease (NAFLD) is featured by increased plasma very low density lipoproteins (VLDL). The extent to which plasma apolipoprotein E (ApoE) levels are elevated in NAFLD is unclear. We determined whether plasma ApoE is elevated in subjects with suspected NAFLD. Plasma ApoE and...

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Autores principales: van den Berg, Eline H., Corsetti, James P., Bakker, Stephan J. L., Dullaart, Robin P. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684074/
https://www.ncbi.nlm.nih.gov/pubmed/31386691
http://dx.doi.org/10.1371/journal.pone.0220659
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author van den Berg, Eline H.
Corsetti, James P.
Bakker, Stephan J. L.
Dullaart, Robin P. F.
author_facet van den Berg, Eline H.
Corsetti, James P.
Bakker, Stephan J. L.
Dullaart, Robin P. F.
author_sort van den Berg, Eline H.
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is featured by increased plasma very low density lipoproteins (VLDL). The extent to which plasma apolipoprotein E (ApoE) levels are elevated in NAFLD is unclear. We determined whether plasma ApoE is elevated in subjects with suspected NAFLD. Plasma ApoE and genotypes were determined in 6,762 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. A Fatty Liver Index (FLI) ≥ 60 was used as a proxy of NAFLD. A total of 1,834 participants had a FLI ≥ 60, which coincided with increased triglycerides, non-HDL cholesterol, ApoB and ApoE (all P<0.001). In multivariable linear regression analysis, plasma ApoE levels were positively associated with an elevated FLI when taking account of ApoE genotypes and other clinical and laboratory covariates (fully adjusted model: β = 0.201, P<0.001). Stratified analysis for ApoE genotypes (ApoE ε3ε3 homozygotes, ApoE ε2 carriers, and ApoE ε3ε4 and ε4ε4 carriers combined), also showed positive associations of plasma ApoE levels with an elevated FLI in each group (all P<0.001). In conclusion, it is suggested that NAFLD is characterized by increased plasma ApoE levels, even when taking account of the various ApoE genotypes. Increased plasma ApoE may contribute to altered VLDL metabolism and to increased atherosclerosis susceptibility in NAFLD.
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spelling pubmed-66840742019-08-15 Plasma ApoE elevations are associated with NAFLD: The PREVEND Study van den Berg, Eline H. Corsetti, James P. Bakker, Stephan J. L. Dullaart, Robin P. F. PLoS One Research Article Non-alcoholic fatty liver disease (NAFLD) is featured by increased plasma very low density lipoproteins (VLDL). The extent to which plasma apolipoprotein E (ApoE) levels are elevated in NAFLD is unclear. We determined whether plasma ApoE is elevated in subjects with suspected NAFLD. Plasma ApoE and genotypes were determined in 6,762 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. A Fatty Liver Index (FLI) ≥ 60 was used as a proxy of NAFLD. A total of 1,834 participants had a FLI ≥ 60, which coincided with increased triglycerides, non-HDL cholesterol, ApoB and ApoE (all P<0.001). In multivariable linear regression analysis, plasma ApoE levels were positively associated with an elevated FLI when taking account of ApoE genotypes and other clinical and laboratory covariates (fully adjusted model: β = 0.201, P<0.001). Stratified analysis for ApoE genotypes (ApoE ε3ε3 homozygotes, ApoE ε2 carriers, and ApoE ε3ε4 and ε4ε4 carriers combined), also showed positive associations of plasma ApoE levels with an elevated FLI in each group (all P<0.001). In conclusion, it is suggested that NAFLD is characterized by increased plasma ApoE levels, even when taking account of the various ApoE genotypes. Increased plasma ApoE may contribute to altered VLDL metabolism and to increased atherosclerosis susceptibility in NAFLD. Public Library of Science 2019-08-06 /pmc/articles/PMC6684074/ /pubmed/31386691 http://dx.doi.org/10.1371/journal.pone.0220659 Text en © 2019 van den Berg et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
van den Berg, Eline H.
Corsetti, James P.
Bakker, Stephan J. L.
Dullaart, Robin P. F.
Plasma ApoE elevations are associated with NAFLD: The PREVEND Study
title Plasma ApoE elevations are associated with NAFLD: The PREVEND Study
title_full Plasma ApoE elevations are associated with NAFLD: The PREVEND Study
title_fullStr Plasma ApoE elevations are associated with NAFLD: The PREVEND Study
title_full_unstemmed Plasma ApoE elevations are associated with NAFLD: The PREVEND Study
title_short Plasma ApoE elevations are associated with NAFLD: The PREVEND Study
title_sort plasma apoe elevations are associated with nafld: the prevend study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684074/
https://www.ncbi.nlm.nih.gov/pubmed/31386691
http://dx.doi.org/10.1371/journal.pone.0220659
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