HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin

The human immunodeficiency virus (HIV-1 virus) exploits several host factors for assembly, infection, and replication within the infected cells. In this work, we describe the evidence for an interaction of the N-terminal domain of the HIV-1 capsid protein with human calmodulin. The precise role of t...

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Autores principales: Tzou, Ywh-Min, Shin, Ronald, Krishna, N. Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684243/
https://www.ncbi.nlm.nih.gov/pubmed/31388391
http://dx.doi.org/10.1177/1934578X19849190
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author Tzou, Ywh-Min
Shin, Ronald
Krishna, N. Rama
author_facet Tzou, Ywh-Min
Shin, Ronald
Krishna, N. Rama
author_sort Tzou, Ywh-Min
collection PubMed
description The human immunodeficiency virus (HIV-1 virus) exploits several host factors for assembly, infection, and replication within the infected cells. In this work, we describe the evidence for an interaction of the N-terminal domain of the HIV-1 capsid protein with human calmodulin. The precise role of this interaction within the life cycle of the HIV-1 virus is yet to be defined. Potential roles for this interaction in the viral capsid uncoating are discussed.
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spelling pubmed-66842432019-08-06 HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin Tzou, Ywh-Min Shin, Ronald Krishna, N. Rama Nat Prod Commun Article The human immunodeficiency virus (HIV-1 virus) exploits several host factors for assembly, infection, and replication within the infected cells. In this work, we describe the evidence for an interaction of the N-terminal domain of the HIV-1 capsid protein with human calmodulin. The precise role of this interaction within the life cycle of the HIV-1 virus is yet to be defined. Potential roles for this interaction in the viral capsid uncoating are discussed. 2019-05-28 2019-05 /pmc/articles/PMC6684243/ /pubmed/31388391 http://dx.doi.org/10.1177/1934578X19849190 Text en This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Tzou, Ywh-Min
Shin, Ronald
Krishna, N. Rama
HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin
title HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin
title_full HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin
title_fullStr HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin
title_full_unstemmed HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin
title_short HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin
title_sort hiv-1 virus interactions with host proteins: interaction of the n-terminal domain of the hiv-1 capsid protein with human calmodulin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684243/
https://www.ncbi.nlm.nih.gov/pubmed/31388391
http://dx.doi.org/10.1177/1934578X19849190
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AT krishnanrama hiv1virusinteractionswithhostproteinsinteractionofthenterminaldomainofthehiv1capsidproteinwithhumancalmodulin

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