Single-Cell Analysis Suggests that Ongoing Affinity Maturation Drives the Emergence of Pemphigus Vulgaris Autoimmune Disease

Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering sores on skin and mucosal membranes, caused by autoantibodies primarily targeting the cellular adhesion protein, desmoglein-3 (Dsg3). To better understand how Dsg3-specific autoantibodies develop and cause disease in humans...

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Detalles Bibliográficos
Autores principales: Cho, Alice, Caldara, Amber L., Ran, Nina A., Menne, Zach, Kauffman, Robert C., Affer, Maurizio, Llovet, Alexandra, Norwood, Carson, Scanlan, Aaron, Mantus, Grace, Bradley, Bridget, Zimmer, Stephanie, Schmidt, Thomas, Hertl, Michael, Payne, Aimee S., Feldman, Ron, Kowalczyk, Andrew P., Wrammert, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684256/
https://www.ncbi.nlm.nih.gov/pubmed/31340153
http://dx.doi.org/10.1016/j.celrep.2019.06.066

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