Anosognosia for hemiplegia as a tripartite disconnection syndrome

The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we w...

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Detalles Bibliográficos
Autores principales: Pacella, Valentina, Foulon, Chris, Jenkinson, Paul M, Scandola, Michele, Bertagnoli, Sara, Avesani, Renato, Fotopoulou, Aikaterini, Moro, Valentina, Thiebaut de Schotten, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684265/
https://www.ncbi.nlm.nih.gov/pubmed/31383259
http://dx.doi.org/10.7554/eLife.46075
Descripción
Sumario:The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.

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