Anosognosia for hemiplegia as a tripartite disconnection syndrome

The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we w...

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Autores principales: Pacella, Valentina, Foulon, Chris, Jenkinson, Paul M, Scandola, Michele, Bertagnoli, Sara, Avesani, Renato, Fotopoulou, Aikaterini, Moro, Valentina, Thiebaut de Schotten, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684265/
https://www.ncbi.nlm.nih.gov/pubmed/31383259
http://dx.doi.org/10.7554/eLife.46075
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author Pacella, Valentina
Foulon, Chris
Jenkinson, Paul M
Scandola, Michele
Bertagnoli, Sara
Avesani, Renato
Fotopoulou, Aikaterini
Moro, Valentina
Thiebaut de Schotten, Michel
author_facet Pacella, Valentina
Foulon, Chris
Jenkinson, Paul M
Scandola, Michele
Bertagnoli, Sara
Avesani, Renato
Fotopoulou, Aikaterini
Moro, Valentina
Thiebaut de Schotten, Michel
author_sort Pacella, Valentina
collection PubMed
description The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.
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spelling pubmed-66842652019-08-09 Anosognosia for hemiplegia as a tripartite disconnection syndrome Pacella, Valentina Foulon, Chris Jenkinson, Paul M Scandola, Michele Bertagnoli, Sara Avesani, Renato Fotopoulou, Aikaterini Moro, Valentina Thiebaut de Schotten, Michel eLife Neuroscience The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems. eLife Sciences Publications, Ltd 2019-08-06 /pmc/articles/PMC6684265/ /pubmed/31383259 http://dx.doi.org/10.7554/eLife.46075 Text en © 2019, Pacella et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Pacella, Valentina
Foulon, Chris
Jenkinson, Paul M
Scandola, Michele
Bertagnoli, Sara
Avesani, Renato
Fotopoulou, Aikaterini
Moro, Valentina
Thiebaut de Schotten, Michel
Anosognosia for hemiplegia as a tripartite disconnection syndrome
title Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_full Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_fullStr Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_full_unstemmed Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_short Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_sort anosognosia for hemiplegia as a tripartite disconnection syndrome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684265/
https://www.ncbi.nlm.nih.gov/pubmed/31383259
http://dx.doi.org/10.7554/eLife.46075
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