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ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form I(Ks) channels that regulate heart rhythm. KCNE1 suppresses the IO st...

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Detalles Bibliográficos
Autores principales:	Hou, Panpan, Shi, Jingyi, White, Kelli McFarland, Gao, Yuan, Cui, Jianmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684268/ https://www.ncbi.nlm.nih.gov/pubmed/31329101 http://dx.doi.org/10.7554/eLife.48576

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