Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

BDNF/TrkB neurotrophic signaling regulates neuronal development, differentiation, and survival, and deficient BDNF/TrkB activity underlies neurodegeneration in Alzheimer’s disease (AD). However, exactly how BDNF/TrkB participates in AD pathology remains unclear. Here, we show that deprivation of BDN...

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Detalles Bibliográficos
Autores principales: Wang, Zhi-Hao, Xiang, Jie, Liu, Xia, Yu, Shan Ping, Manfredsson, Fredric P., Sandoval, Ivette M., Wu, Shengxi, Wang, Jian-Zhi, Ye, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684282/
https://www.ncbi.nlm.nih.gov/pubmed/31315045
http://dx.doi.org/10.1016/j.celrep.2019.06.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684282/
https://www.ncbi.nlm.nih.gov/pubmed/31315045
http://dx.doi.org/10.1016/j.celrep.2019.06.054

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