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Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient
BACKGROUND: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients. CASE PRESENTATION: A 53-y...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684424/ https://www.ncbi.nlm.nih.gov/pubmed/31406542 http://dx.doi.org/10.3889/oamjms.2019.471 |
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author | Triningrat, AA Mas Putrawati Budi, Ni Made Wasiastiti Juliari, IGAM Surasmiati, Ni Made Ayu Siska, Siska Suryaningrum, IGA Ratna |
author_facet | Triningrat, AA Mas Putrawati Budi, Ni Made Wasiastiti Juliari, IGAM Surasmiati, Ni Made Ayu Siska, Siska Suryaningrum, IGA Ratna |
author_sort | Triningrat, AA Mas Putrawati |
collection | PubMed |
description | BACKGROUND: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients. CASE PRESENTATION: A 53-years old, bisexual, male patient whose initial presentation was a blurry vision on the left eye. History of a painless genital lesion, HIV infection (+) on ARV therapy. The visual acuity of hand movement (HM), RAPD (+), with vitreous opacities and optic disc swelling. The OCT RNFL showed neural layer thickening in all areas. VEP showed increased P100 latency, normal head and orbital CT scan. High VDRL and TPHA titer. Lumbar puncture examination showed non-reactive VDRL. Treated with topical prednisolone eye drops, oral neurotropic vitamin, and intramuscular injection of Benzathine Penicillin G. Diagnosed with OS neuroretinitis et causa syphilis infection, HIV stage II on HAART. Follow up in 2 months, the visual acuity improved, and serology post-therapy VDRL was decreased. CONCLUSION: High accuracy is needed for screening signs and symptoms in syphilis patients because of the varied clinical manifestations. Ocular syphilis manifestation in HIV has a higher risk for neurologic complications and the risk of failing treatment with the standard regimen. |
format | Online Article Text |
id | pubmed-6684424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-66844242019-08-12 Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient Triningrat, AA Mas Putrawati Budi, Ni Made Wasiastiti Juliari, IGAM Surasmiati, Ni Made Ayu Siska, Siska Suryaningrum, IGA Ratna Open Access Maced J Med Sci Case Report BACKGROUND: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients. CASE PRESENTATION: A 53-years old, bisexual, male patient whose initial presentation was a blurry vision on the left eye. History of a painless genital lesion, HIV infection (+) on ARV therapy. The visual acuity of hand movement (HM), RAPD (+), with vitreous opacities and optic disc swelling. The OCT RNFL showed neural layer thickening in all areas. VEP showed increased P100 latency, normal head and orbital CT scan. High VDRL and TPHA titer. Lumbar puncture examination showed non-reactive VDRL. Treated with topical prednisolone eye drops, oral neurotropic vitamin, and intramuscular injection of Benzathine Penicillin G. Diagnosed with OS neuroretinitis et causa syphilis infection, HIV stage II on HAART. Follow up in 2 months, the visual acuity improved, and serology post-therapy VDRL was decreased. CONCLUSION: High accuracy is needed for screening signs and symptoms in syphilis patients because of the varied clinical manifestations. Ocular syphilis manifestation in HIV has a higher risk for neurologic complications and the risk of failing treatment with the standard regimen. Republic of Macedonia 2019-06-25 /pmc/articles/PMC6684424/ /pubmed/31406542 http://dx.doi.org/10.3889/oamjms.2019.471 Text en Copyright: © 2019 AA Mas Putrawati Triningrat, Ni Made Wasiastiti Budi, IGAM Juliari; Ni Made Ayu Surasmiati, Siska Siska, IGA Ratna Suryaningrum. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Case Report Triningrat, AA Mas Putrawati Budi, Ni Made Wasiastiti Juliari, IGAM Surasmiati, Ni Made Ayu Siska, Siska Suryaningrum, IGA Ratna Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient |
title | Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient |
title_full | Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient |
title_fullStr | Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient |
title_full_unstemmed | Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient |
title_short | Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient |
title_sort | neuroretinitis syphilis in human immunodeficiency virus-infected patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684424/ https://www.ncbi.nlm.nih.gov/pubmed/31406542 http://dx.doi.org/10.3889/oamjms.2019.471 |
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