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Association between the Gut Microbiota and Obesity

BACKGROUND: People co-evolved with members of the microbiota and developed, used and adapted many complex immune mechanisms, which are used for monitoring and control of the microbiota. The gut microbiota in cooperation with humans became its essential part, so-called “hidden organ” with many import...

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Autores principales: Mitev, Kiril, Taleski, Vaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684436/
https://www.ncbi.nlm.nih.gov/pubmed/31406553
http://dx.doi.org/10.3889/oamjms.2019.586
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author Mitev, Kiril
Taleski, Vaso
author_facet Mitev, Kiril
Taleski, Vaso
author_sort Mitev, Kiril
collection PubMed
description BACKGROUND: People co-evolved with members of the microbiota and developed, used and adapted many complex immune mechanisms, which are used for monitoring and control of the microbiota. The gut microbiota in cooperation with humans became its essential part, so-called “hidden organ” with many important and indispensable functions. Quantitative and/or qualitative deficiency of the gut microbiota (dysbiosis) probably is a basis of many disorders, including obesity. AIM: To present an overview of the possible association between gut microbiota and obesity. METHODS: Meta-analysis of available scientific and published data including PubMed, Web of Science, Scopus and Cochrane Library. RESULTS: In the intestinal microbiota at obese people is detected a specific increase in the proportion between class Firmicutes and Bacteroidetes despite the non-obese people. Also, it is detected a decrease in this proportion if the person lost weight. These facts may be secondary to obesity. The colonisation of germ-free mice with microbiota from ordinarily feed or obese mice, without changes in the feed style leads to increase body fat to more than 50%. CONCLUSION: The human gut microbiota directly affects the food digestion, absorption and metabolism. The gut microbiota of obese people has a higher capacity for receiving energy from the food than the microbiota at slim people. The gut microbiota affects appetite control and energy balance. Lifestyle and food regimen affect the diversity of the gut microbiota and the presence of dysbiosis.
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spelling pubmed-66844362019-08-12 Association between the Gut Microbiota and Obesity Mitev, Kiril Taleski, Vaso Open Access Maced J Med Sci Review Article BACKGROUND: People co-evolved with members of the microbiota and developed, used and adapted many complex immune mechanisms, which are used for monitoring and control of the microbiota. The gut microbiota in cooperation with humans became its essential part, so-called “hidden organ” with many important and indispensable functions. Quantitative and/or qualitative deficiency of the gut microbiota (dysbiosis) probably is a basis of many disorders, including obesity. AIM: To present an overview of the possible association between gut microbiota and obesity. METHODS: Meta-analysis of available scientific and published data including PubMed, Web of Science, Scopus and Cochrane Library. RESULTS: In the intestinal microbiota at obese people is detected a specific increase in the proportion between class Firmicutes and Bacteroidetes despite the non-obese people. Also, it is detected a decrease in this proportion if the person lost weight. These facts may be secondary to obesity. The colonisation of germ-free mice with microbiota from ordinarily feed or obese mice, without changes in the feed style leads to increase body fat to more than 50%. CONCLUSION: The human gut microbiota directly affects the food digestion, absorption and metabolism. The gut microbiota of obese people has a higher capacity for receiving energy from the food than the microbiota at slim people. The gut microbiota affects appetite control and energy balance. Lifestyle and food regimen affect the diversity of the gut microbiota and the presence of dysbiosis. Republic of Macedonia 2019-06-29 /pmc/articles/PMC6684436/ /pubmed/31406553 http://dx.doi.org/10.3889/oamjms.2019.586 Text en Copyright: © 2019 Kiril Mitev, Vaso Taleski. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Review Article
Mitev, Kiril
Taleski, Vaso
Association between the Gut Microbiota and Obesity
title Association between the Gut Microbiota and Obesity
title_full Association between the Gut Microbiota and Obesity
title_fullStr Association between the Gut Microbiota and Obesity
title_full_unstemmed Association between the Gut Microbiota and Obesity
title_short Association between the Gut Microbiota and Obesity
title_sort association between the gut microbiota and obesity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684436/
https://www.ncbi.nlm.nih.gov/pubmed/31406553
http://dx.doi.org/10.3889/oamjms.2019.586
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