On inotropic effects of UTP in the human heart

Uridine 5′-triphosphate (UTP) exerts a positive inotropic effect (PIE) in isolated electrically driven isolated right atrial trabeculae carneae from patients undergoing heart surgery. This review discusses some aspects of the current knowledge on the putative receptor(s) involved and the potential b...

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Detalles Bibliográficos
Autores principales: Neumann, J., Hofmann, B., Gergs, U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684494/
https://www.ncbi.nlm.nih.gov/pubmed/31406941
http://dx.doi.org/10.1016/j.heliyon.2019.e02197
Descripción
Sumario:Uridine 5′-triphosphate (UTP) exerts a positive inotropic effect (PIE) in isolated electrically driven isolated right atrial trabeculae carneae from patients undergoing heart surgery. This review discusses some aspects of the current knowledge on the putative receptor(s) involved and the potential biochemical transduction steps leading to the PIE.

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