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Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
Glomangiopericytoma (GPC) is a rare mesenchymal tumor arising from the nasal cavity or paranasal sinuses. GPC was categorized as a borderline and low-malignant-potential tumor by the World Health Organization in 2005 and accounts for less than 0.5% of all sinonasal tumors. We report a case of GPC in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684555/ https://www.ncbi.nlm.nih.gov/pubmed/30206803 http://dx.doi.org/10.1007/s12105-018-0961-z |
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author | Kono, Michihisa Bandoh, Nobuyuki Matsuoka, Ryosuke Goto, Takashi Akahane, Toshiaki Kato, Yasutaka Nakano, Hiroshi Yamaguchi, Tomomi Harabuchi, Yasuaki Nishihara, Hiroshi |
author_facet | Kono, Michihisa Bandoh, Nobuyuki Matsuoka, Ryosuke Goto, Takashi Akahane, Toshiaki Kato, Yasutaka Nakano, Hiroshi Yamaguchi, Tomomi Harabuchi, Yasuaki Nishihara, Hiroshi |
author_sort | Kono, Michihisa |
collection | PubMed |
description | Glomangiopericytoma (GPC) is a rare mesenchymal tumor arising from the nasal cavity or paranasal sinuses. GPC was categorized as a borderline and low-malignant-potential tumor by the World Health Organization in 2005 and accounts for less than 0.5% of all sinonasal tumors. We report a case of GPC in a 74-year-old woman with a history of recurrent epistaxis and nasal obstruction. A reddish tumor was seen in the right nasal cavity. Enhanced computed tomography showed a mass lesion occupying the right nasal cavity. The tumor, which originated from the nasal septum in the olfactory fissure area, was resected with 5-mm mucosal margins by endoscopic sinus surgery. Histologic examination revealed a uniform proliferation of oval-to-short spindle-shaped cells beneath the epithelium. Immunohistologic analysis demonstrated the tumor cells were positive for α-smooth muscle actin, β-catenin and Vimentin, and negative for AE1/AE3, Bcl-2, CD34, CD117, Factor VIIIR Ag, S-100 protein, or STAT6. The percentage of Ki-67-positive cells was approximately 5%. Genetic analysis using next-generation sequencing revealed a missense mutation in the CTNNB1 gene (c.110C > G, p.S37C). While other CTNNB1 mutations have been described in GPC; this is the first report of this specific mutation. The mutation was confirmed using Sanger sequencing. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12105-018-0961-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6684555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-66845552019-08-19 Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review Kono, Michihisa Bandoh, Nobuyuki Matsuoka, Ryosuke Goto, Takashi Akahane, Toshiaki Kato, Yasutaka Nakano, Hiroshi Yamaguchi, Tomomi Harabuchi, Yasuaki Nishihara, Hiroshi Head Neck Pathol Original Paper Glomangiopericytoma (GPC) is a rare mesenchymal tumor arising from the nasal cavity or paranasal sinuses. GPC was categorized as a borderline and low-malignant-potential tumor by the World Health Organization in 2005 and accounts for less than 0.5% of all sinonasal tumors. We report a case of GPC in a 74-year-old woman with a history of recurrent epistaxis and nasal obstruction. A reddish tumor was seen in the right nasal cavity. Enhanced computed tomography showed a mass lesion occupying the right nasal cavity. The tumor, which originated from the nasal septum in the olfactory fissure area, was resected with 5-mm mucosal margins by endoscopic sinus surgery. Histologic examination revealed a uniform proliferation of oval-to-short spindle-shaped cells beneath the epithelium. Immunohistologic analysis demonstrated the tumor cells were positive for α-smooth muscle actin, β-catenin and Vimentin, and negative for AE1/AE3, Bcl-2, CD34, CD117, Factor VIIIR Ag, S-100 protein, or STAT6. The percentage of Ki-67-positive cells was approximately 5%. Genetic analysis using next-generation sequencing revealed a missense mutation in the CTNNB1 gene (c.110C > G, p.S37C). While other CTNNB1 mutations have been described in GPC; this is the first report of this specific mutation. The mutation was confirmed using Sanger sequencing. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12105-018-0961-z) contains supplementary material, which is available to authorized users. Springer US 2018-09-11 /pmc/articles/PMC6684555/ /pubmed/30206803 http://dx.doi.org/10.1007/s12105-018-0961-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Kono, Michihisa Bandoh, Nobuyuki Matsuoka, Ryosuke Goto, Takashi Akahane, Toshiaki Kato, Yasutaka Nakano, Hiroshi Yamaguchi, Tomomi Harabuchi, Yasuaki Nishihara, Hiroshi Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review |
title | Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review |
title_full | Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review |
title_fullStr | Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review |
title_full_unstemmed | Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review |
title_short | Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review |
title_sort | glomangiopericytoma of the nasal cavity with ctnnb1 p.s37c mutation: a case report and literature review |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684555/ https://www.ncbi.nlm.nih.gov/pubmed/30206803 http://dx.doi.org/10.1007/s12105-018-0961-z |
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