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Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review

Glomangiopericytoma (GPC) is a rare mesenchymal tumor arising from the nasal cavity or paranasal sinuses. GPC was categorized as a borderline and low-malignant-potential tumor by the World Health Organization in 2005 and accounts for less than 0.5% of all sinonasal tumors. We report a case of GPC in...

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Autores principales: Kono, Michihisa, Bandoh, Nobuyuki, Matsuoka, Ryosuke, Goto, Takashi, Akahane, Toshiaki, Kato, Yasutaka, Nakano, Hiroshi, Yamaguchi, Tomomi, Harabuchi, Yasuaki, Nishihara, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684555/
https://www.ncbi.nlm.nih.gov/pubmed/30206803
http://dx.doi.org/10.1007/s12105-018-0961-z
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author Kono, Michihisa
Bandoh, Nobuyuki
Matsuoka, Ryosuke
Goto, Takashi
Akahane, Toshiaki
Kato, Yasutaka
Nakano, Hiroshi
Yamaguchi, Tomomi
Harabuchi, Yasuaki
Nishihara, Hiroshi
author_facet Kono, Michihisa
Bandoh, Nobuyuki
Matsuoka, Ryosuke
Goto, Takashi
Akahane, Toshiaki
Kato, Yasutaka
Nakano, Hiroshi
Yamaguchi, Tomomi
Harabuchi, Yasuaki
Nishihara, Hiroshi
author_sort Kono, Michihisa
collection PubMed
description Glomangiopericytoma (GPC) is a rare mesenchymal tumor arising from the nasal cavity or paranasal sinuses. GPC was categorized as a borderline and low-malignant-potential tumor by the World Health Organization in 2005 and accounts for less than 0.5% of all sinonasal tumors. We report a case of GPC in a 74-year-old woman with a history of recurrent epistaxis and nasal obstruction. A reddish tumor was seen in the right nasal cavity. Enhanced computed tomography showed a mass lesion occupying the right nasal cavity. The tumor, which originated from the nasal septum in the olfactory fissure area, was resected with 5-mm mucosal margins by endoscopic sinus surgery. Histologic examination revealed a uniform proliferation of oval-to-short spindle-shaped cells beneath the epithelium. Immunohistologic analysis demonstrated the tumor cells were positive for α-smooth muscle actin, β-catenin and Vimentin, and negative for AE1/AE3, Bcl-2, CD34, CD117, Factor VIIIR Ag, S-100 protein, or STAT6. The percentage of Ki-67-positive cells was approximately 5%. Genetic analysis using next-generation sequencing revealed a missense mutation in the CTNNB1 gene (c.110C > G, p.S37C). While other CTNNB1 mutations have been described in GPC; this is the first report of this specific mutation. The mutation was confirmed using Sanger sequencing. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12105-018-0961-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-66845552019-08-19 Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review Kono, Michihisa Bandoh, Nobuyuki Matsuoka, Ryosuke Goto, Takashi Akahane, Toshiaki Kato, Yasutaka Nakano, Hiroshi Yamaguchi, Tomomi Harabuchi, Yasuaki Nishihara, Hiroshi Head Neck Pathol Original Paper Glomangiopericytoma (GPC) is a rare mesenchymal tumor arising from the nasal cavity or paranasal sinuses. GPC was categorized as a borderline and low-malignant-potential tumor by the World Health Organization in 2005 and accounts for less than 0.5% of all sinonasal tumors. We report a case of GPC in a 74-year-old woman with a history of recurrent epistaxis and nasal obstruction. A reddish tumor was seen in the right nasal cavity. Enhanced computed tomography showed a mass lesion occupying the right nasal cavity. The tumor, which originated from the nasal septum in the olfactory fissure area, was resected with 5-mm mucosal margins by endoscopic sinus surgery. Histologic examination revealed a uniform proliferation of oval-to-short spindle-shaped cells beneath the epithelium. Immunohistologic analysis demonstrated the tumor cells were positive for α-smooth muscle actin, β-catenin and Vimentin, and negative for AE1/AE3, Bcl-2, CD34, CD117, Factor VIIIR Ag, S-100 protein, or STAT6. The percentage of Ki-67-positive cells was approximately 5%. Genetic analysis using next-generation sequencing revealed a missense mutation in the CTNNB1 gene (c.110C > G, p.S37C). While other CTNNB1 mutations have been described in GPC; this is the first report of this specific mutation. The mutation was confirmed using Sanger sequencing. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12105-018-0961-z) contains supplementary material, which is available to authorized users. Springer US 2018-09-11 /pmc/articles/PMC6684555/ /pubmed/30206803 http://dx.doi.org/10.1007/s12105-018-0961-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Kono, Michihisa
Bandoh, Nobuyuki
Matsuoka, Ryosuke
Goto, Takashi
Akahane, Toshiaki
Kato, Yasutaka
Nakano, Hiroshi
Yamaguchi, Tomomi
Harabuchi, Yasuaki
Nishihara, Hiroshi
Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
title Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
title_full Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
title_fullStr Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
title_full_unstemmed Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
title_short Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review
title_sort glomangiopericytoma of the nasal cavity with ctnnb1 p.s37c mutation: a case report and literature review
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684555/
https://www.ncbi.nlm.nih.gov/pubmed/30206803
http://dx.doi.org/10.1007/s12105-018-0961-z
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