Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B(12) analog

People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report that mice heterozygous for the mutation have a three-fold increase in basal protein kinase G (PKG) activity, and develop a...

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Detalles Bibliográficos
Autores principales: Schwaerzer, Gerburg K., Kalyanaraman, Hema, Casteel, Darren E., Dalton, Nancy D., Gu, Yusu, Lee, Seunghoe, Zhuang, Shunhui, Wahwah, Nisreen, Schilling, Jan M., Patel, Hemal H., Zhang, Qian, Makino, Ayako, Milewicz, Dianna M., Peterson, Kirk L., Boss, Gerry R., Pilz, Renate B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684604/
https://www.ncbi.nlm.nih.gov/pubmed/31387997
http://dx.doi.org/10.1038/s41467-019-11389-1

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