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A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated (18)F-Fluorination Reactions of Arylstannanes

Recent advancements in (18)F radiochemistry, such as the advent of copper-mediated radiofluorination (CMRF) chemistry, have provided unprecedented access to novel chemically diverse PET probes; however, these multicomponent reactions have come with a new set of complex optimization problems. Design...

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Detalles Bibliográficos
Autores principales:	Bowden, Gregory D., Pichler, Bernd J., Maurer, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684620/ https://www.ncbi.nlm.nih.gov/pubmed/31388076 http://dx.doi.org/10.1038/s41598-019-47846-6

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