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Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke

Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascendi...

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Autores principales: Karbasforoushan, Haleh, Cohen-Adad, Julien, Dewald, Julius P. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684621/
https://www.ncbi.nlm.nih.gov/pubmed/31388003
http://dx.doi.org/10.1038/s41467-019-11244-3
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author Karbasforoushan, Haleh
Cohen-Adad, Julien
Dewald, Julius P. A.
author_facet Karbasforoushan, Haleh
Cohen-Adad, Julien
Dewald, Julius P. A.
author_sort Karbasforoushan, Haleh
collection PubMed
description Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.
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spelling pubmed-66846212019-08-08 Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke Karbasforoushan, Haleh Cohen-Adad, Julien Dewald, Julius P. A. Nat Commun Article Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke. Nature Publishing Group UK 2019-08-06 /pmc/articles/PMC6684621/ /pubmed/31388003 http://dx.doi.org/10.1038/s41467-019-11244-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Karbasforoushan, Haleh
Cohen-Adad, Julien
Dewald, Julius P. A.
Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
title Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
title_full Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
title_fullStr Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
title_full_unstemmed Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
title_short Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
title_sort brainstem and spinal cord mri identifies altered sensorimotor pathways post-stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684621/
https://www.ncbi.nlm.nih.gov/pubmed/31388003
http://dx.doi.org/10.1038/s41467-019-11244-3
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