Cargando…

Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2r(I1565A)) results in partial lethality, overgrowth and intestinal adenoma progression

The cation-independent mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R or IGF2R) traffics IGF2 and M6P ligands between pre-lysosomal and extra-cellular compartments. Specific IGF2 and M6P high-affinity binding occurs via domain-11 and domains-3-5-9, respectively. Mammalian mater...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hughes, Jennifer, Surakhy, Mirvat, Can, Sermet, Ducker, Martin, Davies, Nick, Szele, Francis, Bühnemann, Claudia, Carter, Emma, Trikin, Roman, Crump, Matthew P., Frago, Susana, Hassan, A. Bassim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684648/ https://www.ncbi.nlm.nih.gov/pubmed/31388182 http://dx.doi.org/10.1038/s41598-019-47827-9

Ejemplares similares

Maternal Transmission of a Humanised Igf2r Allele Results in an Igf2 Dependent Hypomorphic and Non-Viable Growth Phenotype
por: Hughes, Jennifer, et al.
Publicado: (2013)

Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth
por: Rezgui, Dellel, et al.
Publicado: (2009)

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
por: Chang, Hua-Pin, et al.
Publicado: (2018)

The Association of Soluble IGF2R and IGF2R Gene Polymorphism with Type 2 Diabetes
por: Chanprasertyothin, Suwannee, et al.
Publicado: (2015)

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes
por: Haley, Victoria L, et al.
Publicado: (2012)

IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa
por: Cannarella, Rossella, et al.
Publicado: (2020)

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
por: Sandovici, Ionel, et al.
Publicado: (2022)

Overgrowth syndromes and pediatric cancers: how many roads lead to IGF2?
por: Bharathavikru, Ruthrothaselvi, et al.
Publicado: (2018)

Does Reduced IGF-1R Signaling in Igf1r (+/−) Mice Alter Aging?
por: Bokov, Alex F., et al.
Publicado: (2011)

Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation
por: Zhou, Chan, et al.
Publicado: (2021)

IGF2R Genetic Variants, Circulating IGF2 Concentrations and Colon Cancer Risk in African Americans and Whites
por: Hoyo, Cathrine, et al.
Publicado: (2012)

Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer
por: Sipos, Ferenc, et al.
Publicado: (2017)

IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling
por: Oliva, Claudia R., et al.
Publicado: (2018)

The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis
por: Liu, Mingzhu, et al.
Publicado: (2013)

Epigenetic consequences of artificial reproductive technologies to the bovine imprinted genes SNRPN, H19/IGF2, and IGF2R
por: Smith, Lawrence C., et al.
Publicado: (2015)

IGF/IGF-1R signal pathway in pain: a promising therapeutic target
por: Ma, Lulin, et al.
Publicado: (2023)

Yak IGF2 Promotes Fibroblast Proliferation Via Suppression of IGF1R and PI3KCG Expression
por: Zhang, Quanwei, et al.
Publicado: (2018)

The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells
por: Xu, Dan-dan, et al.
Publicado: (2018)

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers
por: Dallinga, Marchien G., et al.
Publicado: (2018)

miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R
por: Wang, Haiyang, et al.
Publicado: (2017)

Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth and metastasis via IGF1R and PTK2
por: Xie, Meng, et al.
Publicado: (2022)

Various phenotypes of short stature with heterozygous IGF-1 receptor (IGF1R) mutations
por: Kawashima-Sonoyama, Yuki, et al.
Publicado: (2022)

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2
por: Potalitsyn, Pavlo, et al.
Publicado: (2023)

STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody
por: Lee, Ji-Sun, et al.
Publicado: (2015)

Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes
por: Gardner, Eugene J., et al.
Publicado: (2022)

Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTN(IGF1R)
por: Stueven, Noah A., et al.
Publicado: (2023)

Interaction between IGF-IR and ER Induced by E2 and IGF-I
por: Yu, Zhenghong, et al.
Publicado: (2013)

Molecular Imaging of IGF-1R in Cancer
por: Sun, Yingying, et al.
Publicado: (2017)

Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells
por: Saikali, Zeina, et al.
Publicado: (2008)

The Role of IGF/IGF-1R Signaling in Hepatocellular Carcinomas: Stemness-Related Properties and Drug Resistance
por: Ngo, Mai-Huong Thi, et al.
Publicado: (2021)

Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
por: Zhang, Yinqi, et al.
Publicado: (2021)

Hypoxia‐induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R
por: Seo, Seung Hee, et al.
Publicado: (2022)

Circular RNA identified from Peg3 and Igf2r
por: Perera, Bambarendage P. U., et al.
Publicado: (2018)

Insulin‐like Growth Factor (IGF)‐I, IGF‐binding Protein‐3 and Colorectal Adenomas in Japanese Men
por: Teramukai, Satoshi, et al.
Publicado: (2002)

High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1R Antibody (R1507)
por: Gong, Yixuan, et al.
Publicado: (2009)

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR
por: Aleksic, Tamara, et al.
Publicado: (2016)

Different Epigenetic Alterations Are Associated with Abnormal IGF2/Igf2 Upregulation in Neural Tube Defects
por: Bai, Baoling, et al.
Publicado: (2014)

Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia
por: Zhang, Qidi, et al.
Publicado: (2023)

The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific
por: Meyer, Karolin F., et al.
Publicado: (2018)

Genetic Polymorphisms of IGF1 and IGF1R Genes and Their Effects on Growth Traits in Hulun Buir Sheep
por: Ding, Ning, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u00qi884c2glkgumai5fmfeet1