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The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

New Delhi metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase and hydrolyzes almost all clinically used β-lactam antibiotics. Here we show that the antimicrobial peptide thanatin disrupts the outer membrane of NDM-1-producing bacteria by competitively displacing divalent...

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Detalles Bibliográficos
Autores principales:	Ma, Bo, Fang, Chao, Lu, Linshan, Wang, Mingzhi, Xue, Xiaoyan, Zhou, Ying, Li, Mingkai, Hu, Yue, Luo, Xiaoxing, Hou, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684654/ https://www.ncbi.nlm.nih.gov/pubmed/31388008 http://dx.doi.org/10.1038/s41467-019-11503-3

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