Cargando…

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [(11)C]JNJ-(54173)717. We investigated P2X7 availability, in comparison with avai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crabbé, Melissa, Van der Perren, Anke, Bollaerts, Ilse, Kounelis, Savannah, Baekelandt, Veerle, Bormans, Guy, Casteels, Cindy, Moons, Lieve, Van Laere, Koen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684733/ https://www.ncbi.nlm.nih.gov/pubmed/31417352 http://dx.doi.org/10.3389/fnins.2019.00799

Ejemplares similares

Identifying a glucose metabolic brain pattern in an adeno-associated viral vector based rat model for Parkinson’s disease using (18)F-FDG PET imaging
por: Devrome, Martijn, et al.
Publicado: (2019)

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease
por: Gelders, Géraldine, et al.
Publicado: (2018)

Construction and Evaluation of Quantitative Small-Animal PET Probabilistic Atlases for [(18)F]FDG and [(18)F]FECT Functional Mapping of the Mouse Brain
por: Casteels, Cindy, et al.
Publicado: (2013)

Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study
por: Crabbé, Melissa, et al.
Publicado: (2019)

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System
por: Bollaerts, Ilse, et al.
Publicado: (2017)

Automated quantitative gait analysis in animal models of movement disorders
por: Vandeputte, Caroline, et al.
Publicado: (2010)

Volume-of-interest-based supervised cluster analysis for pseudo-reference region selection in [(18)F]DPA-714 PET imaging of the rat brain
por: Vieira, Igor Fagner, et al.
Publicado: (2018)

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease
por: Torre-Muruzabal, Teresa, et al.
Publicado: (2019)

Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish
por: Bollaerts, Ilse, et al.
Publicado: (2019)

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
por: Van der Perren, Anke, et al.
Publicado: (2020)

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
por: Peralta Ramos, Javier María, et al.
Publicado: (2019)

Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT
por: Declercq, Lieven D., et al.
Publicado: (2016)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein
por: Bentea, Eduard, et al.
Publicado: (2015)

Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [(11)C]MA2 and [(18)F]MA3
por: Ahamed, Muneer, et al.
Publicado: (2016)

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB
por: Dekeyster, Eline, et al.
Publicado: (2015)

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
por: Oliveras-Salvá, Marusela, et al.
Publicado: (2013)

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation
por: Cabezudo, Diego, et al.
Publicado: (2020)

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

(18)F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study
por: Emonds, Kimy M, et al.
Publicado: (2013)

Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission
por: Ooms, Maarten, et al.
Publicado: (2016)

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models
por: Wang, Weihua, et al.
Publicado: (2019)

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease
por: Baekelandt, Veerle, et al.
Publicado: (2020)

Rodent models of neuroinflammation for Alzheimer’s disease
por: Nazem, Amir, et al.
Publicado: (2015)

Human biodistribution and dosimetry of [(11)C]-UCB-J, a PET radiotracer for imaging synaptic density
por: Cawthorne, Christopher, et al.
Publicado: (2021)

Binding of [(18)F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients
por: Schaeverbeke, Jolien, et al.
Publicado: (2019)

Tympanic, Infrared Skin, and Temporal Artery Scan Thermometers Compared with Rectal Measurement in Children: A Real-Life Assessment
por: Allegaert, Karel, et al.
Publicado: (2014)

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity
por: Veys, Koen, et al.
Publicado: (2020)

Neuroinflammation as potential precursor of leukoencephalopathy in early-stage breast cancer patients: A cross-sectional PET-MRI study
por: Schroyen, Gwen, et al.
Publicado: (2022)

Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease
por: Kim, Han Wool, et al.
Publicado: (2018)

Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain
por: Rebelo, Ana Lúcia, et al.
Publicado: (2021)

Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
por: Troncoso-Escudero, Paulina, et al.
Publicado: (2018)

Glycosphingolipids and neuroinflammation in Parkinson’s disease
por: Belarbi, Karim, et al.
Publicado: (2020)

Biomarker of Neuroinflammation in Parkinson’s Disease
por: Liu, Tsai-Wei, et al.
Publicado: (2022)

Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice
por: De Groef, Lies, et al.
Publicado: (2016)

Cholinergic depletion and basal forebrain volume in primary progressive aphasia
por: Schaeverbeke, Jolien, et al.
Publicado: (2016)

Neuroinflammation and Its Association with Cognition, Neuronal Markers and Peripheral Inflammation after Chemotherapy for Breast Cancer
por: Schroyen, Gwen, et al.
Publicado: (2021)

Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes
por: Devrome, Martijn, et al.
Publicado: (2018)

Non-invasive characterization of amyotrophic lateral sclerosis in a hTDP-43(A315T) mouse model: A PET-MR study
por: Weerasekera, Akila, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cq2g2j097ds8p11f7sqi2mhvrm