An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma

Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule o...

Descripción completa

Detalles Bibliográficos
Autores principales: Monti, Eleonora, Dono, Mariella, Gonella, Edoardo, Spina, Bruno, Pitto, Francesca, Petrogalli, Floriana, Conte, Lucia, Ambrosetti, Eleonora, Minuto, Michele N., Ansaldo, Gian Luca, Morbelli, Silvia, Zupo, Simona, Giusti, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684754/
https://www.ncbi.nlm.nih.gov/pubmed/31417495
http://dx.doi.org/10.3389/fendo.2019.00513
_version_ 1783442300576202752
author Monti, Eleonora
Dono, Mariella
Gonella, Edoardo
Spina, Bruno
Pitto, Francesca
Petrogalli, Floriana
Conte, Lucia
Ambrosetti, Eleonora
Minuto, Michele N.
Ansaldo, Gian Luca
Morbelli, Silvia
Zupo, Simona
Giusti, Massimo
author_facet Monti, Eleonora
Dono, Mariella
Gonella, Edoardo
Spina, Bruno
Pitto, Francesca
Petrogalli, Floriana
Conte, Lucia
Ambrosetti, Eleonora
Minuto, Michele N.
Ansaldo, Gian Luca
Morbelli, Silvia
Zupo, Simona
Giusti, Massimo
author_sort Monti, Eleonora
collection PubMed
description Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations. The results showed that the cutaneous metastasis was BRAF wild-type and TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers.
format Online
Article
Text
id pubmed-6684754
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-66847542019-08-15 An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma Monti, Eleonora Dono, Mariella Gonella, Edoardo Spina, Bruno Pitto, Francesca Petrogalli, Floriana Conte, Lucia Ambrosetti, Eleonora Minuto, Michele N. Ansaldo, Gian Luca Morbelli, Silvia Zupo, Simona Giusti, Massimo Front Endocrinol (Lausanne) Endocrinology Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of BRAF/RAS and TERT promoter mutations. The results showed that the cutaneous metastasis was BRAF wild-type and TERT promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers. Frontiers Media S.A. 2019-07-31 /pmc/articles/PMC6684754/ /pubmed/31417495 http://dx.doi.org/10.3389/fendo.2019.00513 Text en Copyright © 2019 Monti, Dono, Gonella, Spina, Pitto, Petrogalli, Conte, Ambrosetti, Minuto, Ansaldo, Morbelli, Zupo and Giusti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Monti, Eleonora
Dono, Mariella
Gonella, Edoardo
Spina, Bruno
Pitto, Francesca
Petrogalli, Floriana
Conte, Lucia
Ambrosetti, Eleonora
Minuto, Michele N.
Ansaldo, Gian Luca
Morbelli, Silvia
Zupo, Simona
Giusti, Massimo
An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
title An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
title_full An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
title_fullStr An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
title_full_unstemmed An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
title_short An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma
title_sort h-tert mutated skin metastasis as first occurrence in a case of follicular thyroid carcinoma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684754/
https://www.ncbi.nlm.nih.gov/pubmed/31417495
http://dx.doi.org/10.3389/fendo.2019.00513
work_keys_str_mv AT montieleonora anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT donomariella anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT gonellaedoardo anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT spinabruno anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT pittofrancesca anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT petrogallifloriana anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT contelucia anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT ambrosettieleonora anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT minutomichelen anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT ansaldogianluca anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT morbellisilvia anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT zuposimona anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT giustimassimo anhtertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT montieleonora htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT donomariella htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT gonellaedoardo htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT spinabruno htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT pittofrancesca htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT petrogallifloriana htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT contelucia htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT ambrosettieleonora htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT minutomichelen htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT ansaldogianluca htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT morbellisilvia htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT zuposimona htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma
AT giustimassimo htertmutatedskinmetastasisasfirstoccurrenceinacaseoffollicularthyroidcarcinoma

Ejemplares similares