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Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the urine and target organs. Instead, plasma arsenicals m...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684877/ https://www.ncbi.nlm.nih.gov/pubmed/30728485 http://dx.doi.org/10.1038/s41370-019-0121-x |
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author | Bommarito, Paige A. Beck, Rowan Douillet, Christelle Del Razo, Luz M. Garcia-Vargas, Gonzalo-G. Valenzuela, Olga L. Sanchez-Peña, Luz C. Styblo, Mirek Fry, Rebecca C. |
author_facet | Bommarito, Paige A. Beck, Rowan Douillet, Christelle Del Razo, Luz M. Garcia-Vargas, Gonzalo-G. Valenzuela, Olga L. Sanchez-Peña, Luz C. Styblo, Mirek Fry, Rebecca C. |
author_sort | Bommarito, Paige A. |
collection | PubMed |
description | Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the urine and target organs. Instead, plasma arsenicals may better represent internal dose and capture target organ exposure to arsenicals. Drinking water iAs, plasma and urinary arsenicals were quantified individuals living in the Zimapan and Lagunera regions of Mexico. The relationship between drinking water iAs and plasma arsenicals was examined using both Spearman correlations and multivariable linear regression models. In addition, the distribution of arsenicals in plasma and urine was examined and the association between plasma and urinary arsenicals was assessed using both Spearman correlations and multivariable linear regression models. Levels of iAs in drinking water were significantly associated with plasma arsenicals in unadjusted and adjusted analyses and the strength of these associations was similar to that of drinking water iAs and urinary arsenicals. These results suggest that plasma arsenicals are reliable biomarkers of iAs exposure via drinking water. However, there were notable differences between the profiles of arsenicals in the plasma and the urine. Key differences between the proportions of arsenicals in plasma and urine may indicate that urine and plasma arsenicals reflect different aspects of iAs toxicokinetics, including metabolism and excretion.. |
format | Online Article Text |
id | pubmed-6684877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-66848772019-08-07 Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic Bommarito, Paige A. Beck, Rowan Douillet, Christelle Del Razo, Luz M. Garcia-Vargas, Gonzalo-G. Valenzuela, Olga L. Sanchez-Peña, Luz C. Styblo, Mirek Fry, Rebecca C. J Expo Sci Environ Epidemiol Article Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the urine and target organs. Instead, plasma arsenicals may better represent internal dose and capture target organ exposure to arsenicals. Drinking water iAs, plasma and urinary arsenicals were quantified individuals living in the Zimapan and Lagunera regions of Mexico. The relationship between drinking water iAs and plasma arsenicals was examined using both Spearman correlations and multivariable linear regression models. In addition, the distribution of arsenicals in plasma and urine was examined and the association between plasma and urinary arsenicals was assessed using both Spearman correlations and multivariable linear regression models. Levels of iAs in drinking water were significantly associated with plasma arsenicals in unadjusted and adjusted analyses and the strength of these associations was similar to that of drinking water iAs and urinary arsenicals. These results suggest that plasma arsenicals are reliable biomarkers of iAs exposure via drinking water. However, there were notable differences between the profiles of arsenicals in the plasma and the urine. Key differences between the proportions of arsenicals in plasma and urine may indicate that urine and plasma arsenicals reflect different aspects of iAs toxicokinetics, including metabolism and excretion.. 2019-02-06 2019-09 /pmc/articles/PMC6684877/ /pubmed/30728485 http://dx.doi.org/10.1038/s41370-019-0121-x Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Bommarito, Paige A. Beck, Rowan Douillet, Christelle Del Razo, Luz M. Garcia-Vargas, Gonzalo-G. Valenzuela, Olga L. Sanchez-Peña, Luz C. Styblo, Mirek Fry, Rebecca C. Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic |
title | Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic |
title_full | Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic |
title_fullStr | Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic |
title_full_unstemmed | Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic |
title_short | Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic |
title_sort | evaluation of plasma arsenicals as potential biomarkers of exposure to inorganic arsenic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684877/ https://www.ncbi.nlm.nih.gov/pubmed/30728485 http://dx.doi.org/10.1038/s41370-019-0121-x |
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