Cargando…

Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic

Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the urine and target organs. Instead, plasma arsenicals m...

Descripción completa

Detalles Bibliográficos
Autores principales: Bommarito, Paige A., Beck, Rowan, Douillet, Christelle, Del Razo, Luz M., Garcia-Vargas, Gonzalo-G., Valenzuela, Olga L., Sanchez-Peña, Luz C., Styblo, Mirek, Fry, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684877/
https://www.ncbi.nlm.nih.gov/pubmed/30728485
http://dx.doi.org/10.1038/s41370-019-0121-x
_version_ 1783442318738587648
author Bommarito, Paige A.
Beck, Rowan
Douillet, Christelle
Del Razo, Luz M.
Garcia-Vargas, Gonzalo-G.
Valenzuela, Olga L.
Sanchez-Peña, Luz C.
Styblo, Mirek
Fry, Rebecca C.
author_facet Bommarito, Paige A.
Beck, Rowan
Douillet, Christelle
Del Razo, Luz M.
Garcia-Vargas, Gonzalo-G.
Valenzuela, Olga L.
Sanchez-Peña, Luz C.
Styblo, Mirek
Fry, Rebecca C.
author_sort Bommarito, Paige A.
collection PubMed
description Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the urine and target organs. Instead, plasma arsenicals may better represent internal dose and capture target organ exposure to arsenicals. Drinking water iAs, plasma and urinary arsenicals were quantified individuals living in the Zimapan and Lagunera regions of Mexico. The relationship between drinking water iAs and plasma arsenicals was examined using both Spearman correlations and multivariable linear regression models. In addition, the distribution of arsenicals in plasma and urine was examined and the association between plasma and urinary arsenicals was assessed using both Spearman correlations and multivariable linear regression models. Levels of iAs in drinking water were significantly associated with plasma arsenicals in unadjusted and adjusted analyses and the strength of these associations was similar to that of drinking water iAs and urinary arsenicals. These results suggest that plasma arsenicals are reliable biomarkers of iAs exposure via drinking water. However, there were notable differences between the profiles of arsenicals in the plasma and the urine. Key differences between the proportions of arsenicals in plasma and urine may indicate that urine and plasma arsenicals reflect different aspects of iAs toxicokinetics, including metabolism and excretion..
format Online
Article
Text
id pubmed-6684877
institution National Center for Biotechnology Information
language English
publishDate 2019
record_format MEDLINE/PubMed
spelling pubmed-66848772019-08-07 Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic Bommarito, Paige A. Beck, Rowan Douillet, Christelle Del Razo, Luz M. Garcia-Vargas, Gonzalo-G. Valenzuela, Olga L. Sanchez-Peña, Luz C. Styblo, Mirek Fry, Rebecca C. J Expo Sci Environ Epidemiol Article Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the urine and target organs. Instead, plasma arsenicals may better represent internal dose and capture target organ exposure to arsenicals. Drinking water iAs, plasma and urinary arsenicals were quantified individuals living in the Zimapan and Lagunera regions of Mexico. The relationship between drinking water iAs and plasma arsenicals was examined using both Spearman correlations and multivariable linear regression models. In addition, the distribution of arsenicals in plasma and urine was examined and the association between plasma and urinary arsenicals was assessed using both Spearman correlations and multivariable linear regression models. Levels of iAs in drinking water were significantly associated with plasma arsenicals in unadjusted and adjusted analyses and the strength of these associations was similar to that of drinking water iAs and urinary arsenicals. These results suggest that plasma arsenicals are reliable biomarkers of iAs exposure via drinking water. However, there were notable differences between the profiles of arsenicals in the plasma and the urine. Key differences between the proportions of arsenicals in plasma and urine may indicate that urine and plasma arsenicals reflect different aspects of iAs toxicokinetics, including metabolism and excretion.. 2019-02-06 2019-09 /pmc/articles/PMC6684877/ /pubmed/30728485 http://dx.doi.org/10.1038/s41370-019-0121-x Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Bommarito, Paige A.
Beck, Rowan
Douillet, Christelle
Del Razo, Luz M.
Garcia-Vargas, Gonzalo-G.
Valenzuela, Olga L.
Sanchez-Peña, Luz C.
Styblo, Mirek
Fry, Rebecca C.
Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
title Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
title_full Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
title_fullStr Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
title_full_unstemmed Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
title_short Evaluation of Plasma Arsenicals as Potential Biomarkers of Exposure to Inorganic Arsenic
title_sort evaluation of plasma arsenicals as potential biomarkers of exposure to inorganic arsenic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684877/
https://www.ncbi.nlm.nih.gov/pubmed/30728485
http://dx.doi.org/10.1038/s41370-019-0121-x
work_keys_str_mv AT bommaritopaigea evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT beckrowan evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT douilletchristelle evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT delrazoluzm evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT garciavargasgonzalog evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT valenzuelaolgal evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT sanchezpenaluzc evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT styblomirek evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic
AT fryrebeccac evaluationofplasmaarsenicalsaspotentialbiomarkersofexposuretoinorganicarsenic