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Photoreceptor evaluation after successful macular hole closure: an adaptive optics study

OBJECTIVE: To study photoreceptor changes after a successful macular hole surgery using adaptive optics. MATERIALS AND METHODS: Three patients who underwent a successful macular hole surgery were studied. Cone density, spacing, and number of nearest neighbors were analyzed at 2° and 4° of eccentrici...

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Autores principales: Markan, Ashish, Chawla, Rohan, Gupta, Vinay, Tripathi, Manasi, Sharma, Anu, Kumar, Atul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685118/
https://www.ncbi.nlm.nih.gov/pubmed/31432003
http://dx.doi.org/10.1177/2515841419868132
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author Markan, Ashish
Chawla, Rohan
Gupta, Vinay
Tripathi, Manasi
Sharma, Anu
Kumar, Atul
author_facet Markan, Ashish
Chawla, Rohan
Gupta, Vinay
Tripathi, Manasi
Sharma, Anu
Kumar, Atul
author_sort Markan, Ashish
collection PubMed
description OBJECTIVE: To study photoreceptor changes after a successful macular hole surgery using adaptive optics. MATERIALS AND METHODS: Three patients who underwent a successful macular hole surgery were studied. Cone density, spacing, and number of nearest neighbors were analyzed at 2° and 4° of eccentricity in all four quadrants using adaptive optics. RESULTS: All three patients gained a visual acuity better than logMAR 0.477 (Snellen equivalent 6/18) at 6 months following successful macular hole surgery. Following successful closure of the macular hole, photoreceptors were appreciated at 2° and 4° of eccentricity from the center. However, as compared with the fellow normal eye, cell density was reduced significantly in the inferior (12,929.33 ± 2047.50 versus 23,839.67 ± 3711.16 cells/mm(2) at 2°) and temporal quadrant (13,890 ± 3424.26 versus 22,578.67 ± 5651.34 cells/mm(2) at 2°), and intercell spacing was increased significantly in inferior (9.6 ± 0.92 versus 7.14 ± 0.545 µm) and nasal quadrant (8.83 ± 0.39 versus 7.49 ± 0.42 µm). Number of nearest neighbors was unaffected after the hole closure. CONCLUSION: Postoperative recovery of vision after successful closure of the hole occurs because of the migration or shifting of cells from parafoveal retina toward the center. Cells nearest to the hole margin (at 2° eccentricity) appear to shift more as compared with cells which are further away.
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spelling pubmed-66851182019-08-20 Photoreceptor evaluation after successful macular hole closure: an adaptive optics study Markan, Ashish Chawla, Rohan Gupta, Vinay Tripathi, Manasi Sharma, Anu Kumar, Atul Ther Adv Ophthalmol Case Series OBJECTIVE: To study photoreceptor changes after a successful macular hole surgery using adaptive optics. MATERIALS AND METHODS: Three patients who underwent a successful macular hole surgery were studied. Cone density, spacing, and number of nearest neighbors were analyzed at 2° and 4° of eccentricity in all four quadrants using adaptive optics. RESULTS: All three patients gained a visual acuity better than logMAR 0.477 (Snellen equivalent 6/18) at 6 months following successful macular hole surgery. Following successful closure of the macular hole, photoreceptors were appreciated at 2° and 4° of eccentricity from the center. However, as compared with the fellow normal eye, cell density was reduced significantly in the inferior (12,929.33 ± 2047.50 versus 23,839.67 ± 3711.16 cells/mm(2) at 2°) and temporal quadrant (13,890 ± 3424.26 versus 22,578.67 ± 5651.34 cells/mm(2) at 2°), and intercell spacing was increased significantly in inferior (9.6 ± 0.92 versus 7.14 ± 0.545 µm) and nasal quadrant (8.83 ± 0.39 versus 7.49 ± 0.42 µm). Number of nearest neighbors was unaffected after the hole closure. CONCLUSION: Postoperative recovery of vision after successful closure of the hole occurs because of the migration or shifting of cells from parafoveal retina toward the center. Cells nearest to the hole margin (at 2° eccentricity) appear to shift more as compared with cells which are further away. SAGE Publications 2019-08-06 /pmc/articles/PMC6685118/ /pubmed/31432003 http://dx.doi.org/10.1177/2515841419868132 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Series
Markan, Ashish
Chawla, Rohan
Gupta, Vinay
Tripathi, Manasi
Sharma, Anu
Kumar, Atul
Photoreceptor evaluation after successful macular hole closure: an adaptive optics study
title Photoreceptor evaluation after successful macular hole closure: an adaptive optics study
title_full Photoreceptor evaluation after successful macular hole closure: an adaptive optics study
title_fullStr Photoreceptor evaluation after successful macular hole closure: an adaptive optics study
title_full_unstemmed Photoreceptor evaluation after successful macular hole closure: an adaptive optics study
title_short Photoreceptor evaluation after successful macular hole closure: an adaptive optics study
title_sort photoreceptor evaluation after successful macular hole closure: an adaptive optics study
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685118/
https://www.ncbi.nlm.nih.gov/pubmed/31432003
http://dx.doi.org/10.1177/2515841419868132
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