Cargando…

A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial

BACKGROUND: Breast cancer patients have to face a high-risk state during chemotherapy, which involves deterioration of their health including extensive physical deterioration. Face-to-face physical exercise programs have presented low adherence rates during medical treatment, and telehealth systems...

Descripción completa

Detalles Bibliográficos
Autores principales: Ariza-Garcia, Angelica, Lozano-Lozano, Mario, Galiano-Castillo, Noelia, Postigo-Martin, Paula, Arroyo-Morales, Manuel, Cantarero-Villanueva, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685131/
https://www.ncbi.nlm.nih.gov/pubmed/31342907
http://dx.doi.org/10.2196/14418
_version_ 1783442347464327168
author Ariza-Garcia, Angelica
Lozano-Lozano, Mario
Galiano-Castillo, Noelia
Postigo-Martin, Paula
Arroyo-Morales, Manuel
Cantarero-Villanueva, Irene
author_facet Ariza-Garcia, Angelica
Lozano-Lozano, Mario
Galiano-Castillo, Noelia
Postigo-Martin, Paula
Arroyo-Morales, Manuel
Cantarero-Villanueva, Irene
author_sort Ariza-Garcia, Angelica
collection PubMed
description BACKGROUND: Breast cancer patients have to face a high-risk state during chemotherapy, which involves deterioration of their health including extensive physical deterioration. Face-to-face physical exercise programs have presented low adherence rates during medical treatment, and telehealth systems could improve these adherence rates. OBJECTIVE: This study aimed to evaluate the effectiveness of a Web-based exercise program (e-CuidateChemo) to mitigate the side effects of chemotherapy on the physical being, anthropometric aspects, and body composition. METHODS: A total of 68 patients diagnosed with breast cancer, who were undergoing chemotherapy, were enrolled. The patients were categorized into two groups: e-CuidateChemo (n=34) and controls (n=34). The e-CuidateChemo group participated in an adapted 8-week tailored exercise program through a Web-based system. A blinded, trained researcher assessed functional capacity, strength, anthropometric parameters, and body composition. The intervention effects were tested using analysis of covariance and Cohen d tests. RESULTS: Functional capacity improved significantly in the e-CuidateChemo group compared to the control group (6-minute walk test: 62.07 [SD 130.09] m versus –26.34 [SD 82.21] m; 6-minute walk test % distance predicted: 10.81% [SD 22.69%] m versus –4.60% [SD 14.58%]; between-group effect: P=.015 for both). The intervention group also showed significantly improved secondary outcomes such as between-group effects for abdominal (24.93 [SD 26.83] s vs –18.59 [SD 38.69] s), back (12.45 [SD 10.20] kg vs 1.39 [10.72] kg), and lower body (–2.82 [SD 3.75] s vs 1.26 [SD 2.84] s) strength; all P<.001 compared to the control group. CONCLUSIONS: This paper showed that a Web-based exercise program was effective in reversing the detriment in functional capacity and strength due to chemotherapy. TRIAL REGISTRATION: ClinicalTrials.gov NCT02350582; https://clinicaltrials.gov/ct2/show/NCT02350582
format Online
Article
Text
id pubmed-6685131
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher JMIR Publications
record_format MEDLINE/PubMed
spelling pubmed-66851312019-08-20 A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial Ariza-Garcia, Angelica Lozano-Lozano, Mario Galiano-Castillo, Noelia Postigo-Martin, Paula Arroyo-Morales, Manuel Cantarero-Villanueva, Irene J Med Internet Res Original Paper BACKGROUND: Breast cancer patients have to face a high-risk state during chemotherapy, which involves deterioration of their health including extensive physical deterioration. Face-to-face physical exercise programs have presented low adherence rates during medical treatment, and telehealth systems could improve these adherence rates. OBJECTIVE: This study aimed to evaluate the effectiveness of a Web-based exercise program (e-CuidateChemo) to mitigate the side effects of chemotherapy on the physical being, anthropometric aspects, and body composition. METHODS: A total of 68 patients diagnosed with breast cancer, who were undergoing chemotherapy, were enrolled. The patients were categorized into two groups: e-CuidateChemo (n=34) and controls (n=34). The e-CuidateChemo group participated in an adapted 8-week tailored exercise program through a Web-based system. A blinded, trained researcher assessed functional capacity, strength, anthropometric parameters, and body composition. The intervention effects were tested using analysis of covariance and Cohen d tests. RESULTS: Functional capacity improved significantly in the e-CuidateChemo group compared to the control group (6-minute walk test: 62.07 [SD 130.09] m versus –26.34 [SD 82.21] m; 6-minute walk test % distance predicted: 10.81% [SD 22.69%] m versus –4.60% [SD 14.58%]; between-group effect: P=.015 for both). The intervention group also showed significantly improved secondary outcomes such as between-group effects for abdominal (24.93 [SD 26.83] s vs –18.59 [SD 38.69] s), back (12.45 [SD 10.20] kg vs 1.39 [10.72] kg), and lower body (–2.82 [SD 3.75] s vs 1.26 [SD 2.84] s) strength; all P<.001 compared to the control group. CONCLUSIONS: This paper showed that a Web-based exercise program was effective in reversing the detriment in functional capacity and strength due to chemotherapy. TRIAL REGISTRATION: ClinicalTrials.gov NCT02350582; https://clinicaltrials.gov/ct2/show/NCT02350582 JMIR Publications 2019-07-24 /pmc/articles/PMC6685131/ /pubmed/31342907 http://dx.doi.org/10.2196/14418 Text en ©Angelica Ariza-Garcia, Mario Lozano-Lozano, Noelia Galiano-Castillo, Paula Postigo-Martin, Manuel Arroyo-Morales, Irene Cantarero-Villanueva. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 24.07.2019. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.
spellingShingle Original Paper
Ariza-Garcia, Angelica
Lozano-Lozano, Mario
Galiano-Castillo, Noelia
Postigo-Martin, Paula
Arroyo-Morales, Manuel
Cantarero-Villanueva, Irene
A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
title A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
title_full A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
title_fullStr A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
title_full_unstemmed A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
title_short A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
title_sort web-based exercise system (e-cuidatechemo) to counter the side effects of chemotherapy in patients with breast cancer: randomized controlled trial
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685131/
https://www.ncbi.nlm.nih.gov/pubmed/31342907
http://dx.doi.org/10.2196/14418
work_keys_str_mv AT arizagarciaangelica awebbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT lozanolozanomario awebbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT galianocastillonoelia awebbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT postigomartinpaula awebbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT arroyomoralesmanuel awebbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT cantarerovillanuevairene awebbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT arizagarciaangelica webbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT lozanolozanomario webbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT galianocastillonoelia webbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT postigomartinpaula webbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT arroyomoralesmanuel webbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial
AT cantarerovillanuevairene webbasedexercisesystemecuidatechemotocounterthesideeffectsofchemotherapyinpatientswithbreastcancerrandomizedcontrolledtrial