MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner

BACKGROUND: One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the activating receptor NKG2D on NK and CD8 T cells. This shedd...

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Detalles Bibliográficos
Autores principales: Du, Changchun, Bevers, Jack, Cook, Ryan, Lombana, T. Noelle, Rajasekaran, Kamalakannan, Matsumoto, Marissa, Spiess, Christoph, Kim, Jeong M., Ye, Zhengmao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685158/
https://www.ncbi.nlm.nih.gov/pubmed/31387641
http://dx.doi.org/10.1186/s40425-019-0687-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685158/
https://www.ncbi.nlm.nih.gov/pubmed/31387641
http://dx.doi.org/10.1186/s40425-019-0687-9

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