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Designing gene panels for tumor mutational burden estimation: the need to shift from ‘correlation’ to ‘accuracy’
Tumor mutational burden (TMB) assessment is at the forefront in precision medicine. The TMB could represent a biomarker for immune checkpoint inhibitors (ICIs) responses. Whole exome sequencing (WES) is the gold standard to derive the TMB; while targeted next-generation sequencing panels might be mo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685228/ https://www.ncbi.nlm.nih.gov/pubmed/31387639 http://dx.doi.org/10.1186/s40425-019-0681-2 |