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Cox-2 inhibitors in mandibular third molar surgery
Pain control during and after any surgical procedure, is extremely essential for the comfort of patients. Pain killers used routinely act by inhibiting cyclooxygenase to control pain and inflammation. Cox-1 is constitutively expressed in most cell types, including platelets, whereas Cox-2 is absent...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685300/ https://www.ncbi.nlm.nih.gov/pubmed/31406516 http://dx.doi.org/10.25122/jml-2019-0007 |
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author | Janarthanan, K. Adalarasan, S. |
author_facet | Janarthanan, K. Adalarasan, S. |
author_sort | Janarthanan, K. |
collection | PubMed |
description | Pain control during and after any surgical procedure, is extremely essential for the comfort of patients. Pain killers used routinely act by inhibiting cyclooxygenase to control pain and inflammation. Cox-1 is constitutively expressed in most cell types, including platelets, whereas Cox-2 is absent from most healthy tissues but is induced by pro-inflammatory or proliferative stimuli. Cox-1 plays a role in the production of prostaglandins involved in protection of the gastric mucosal layer and thromboxanes (TX) in platelets. Cox-2 generally mediates elevations of prostaglandins associated with inflammation, pain, and pyresis. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen are generally nonselective inhibitors of Coxs. This lack of selectivity has been linked to their propensity to cause gastrointestinal side effects. The new Cox-2 selective inhibitors, or coxibs, show the same anti-inflammatory, analgesic, and antipyretic effects as nonselective NSAIDs but are supposed to have reduced side-effect profiles. This study evaluates whether rofecoxib (50 mg) given one hour pre-operatively or the same drug given one hour post-operatively is more effective in controlling the pain and swelling in mandibular third molar surgery. |
format | Online Article Text |
id | pubmed-6685300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66853002019-08-12 Cox-2 inhibitors in mandibular third molar surgery Janarthanan, K. Adalarasan, S. J Med Life Original Article Pain control during and after any surgical procedure, is extremely essential for the comfort of patients. Pain killers used routinely act by inhibiting cyclooxygenase to control pain and inflammation. Cox-1 is constitutively expressed in most cell types, including platelets, whereas Cox-2 is absent from most healthy tissues but is induced by pro-inflammatory or proliferative stimuli. Cox-1 plays a role in the production of prostaglandins involved in protection of the gastric mucosal layer and thromboxanes (TX) in platelets. Cox-2 generally mediates elevations of prostaglandins associated with inflammation, pain, and pyresis. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen are generally nonselective inhibitors of Coxs. This lack of selectivity has been linked to their propensity to cause gastrointestinal side effects. The new Cox-2 selective inhibitors, or coxibs, show the same anti-inflammatory, analgesic, and antipyretic effects as nonselective NSAIDs but are supposed to have reduced side-effect profiles. This study evaluates whether rofecoxib (50 mg) given one hour pre-operatively or the same drug given one hour post-operatively is more effective in controlling the pain and swelling in mandibular third molar surgery. Carol Davila University Press 2019 /pmc/articles/PMC6685300/ /pubmed/31406516 http://dx.doi.org/10.25122/jml-2019-0007 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Janarthanan, K. Adalarasan, S. Cox-2 inhibitors in mandibular third molar surgery |
title | Cox-2 inhibitors in mandibular third molar surgery |
title_full | Cox-2 inhibitors in mandibular third molar surgery |
title_fullStr | Cox-2 inhibitors in mandibular third molar surgery |
title_full_unstemmed | Cox-2 inhibitors in mandibular third molar surgery |
title_short | Cox-2 inhibitors in mandibular third molar surgery |
title_sort | cox-2 inhibitors in mandibular third molar surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685300/ https://www.ncbi.nlm.nih.gov/pubmed/31406516 http://dx.doi.org/10.25122/jml-2019-0007 |
work_keys_str_mv | AT janarthanank cox2inhibitorsinmandibularthirdmolarsurgery AT adalarasans cox2inhibitorsinmandibularthirdmolarsurgery |