Cargando…

Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran

There is evidence that infection by H. pylori can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the to...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohammadifard, Mahyar, Saremi, Zeinab, Rastgoo, Mahboobe, Akbari, Ehsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685302/
https://www.ncbi.nlm.nih.gov/pubmed/31406519
http://dx.doi.org/10.25122/jml-2019-0012
_version_ 1783442378230595584
author Mohammadifard, Mahyar
Saremi, Zeinab
Rastgoo, Mahboobe
Akbari, Ehsan
author_facet Mohammadifard, Mahyar
Saremi, Zeinab
Rastgoo, Mahboobe
Akbari, Ehsan
author_sort Mohammadifard, Mahyar
collection PubMed
description There is evidence that infection by H. pylori can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the toxic products of the bacterium H. pylori and oxidative injury for hepatocytes which promotes hepatic injury. The present research was aimed at determining the association between H. pylori infection and the prevalence of NAFLD in Birjand, Iran. Two groups were included in this cross-sectional study at the outpatient university clinic. One group had NAFLD (65 patients) and the other group was healthy controls without NAFLD (65 subjects). The diagnosis of NAFLD was performed using abdominal ultrasound examination and the absence of taking steatogenic medications or alcohol. Serum anti-H. pylori IgG and fecal H. pylori antigen were tested for diagnosing of H. pylori infection using ELISA method. H. pylori infection diagnosis was made if both tests were positive. None of the subjects in either group had symptoms related to the digestive system including dyspepsia, GERD (gastroesophageal reflux disease), or epigastric pain suspicious of peptic ulcer disease. There were 37 patients (28.5%) in both NAFLD (22 cases, 33.8%) and control (15 cases, 23.1%) groups whose H. pylori tests (both IgG and fecal antigen) were positive. Statistically, no significant difference was observed between the two studied groups regarding H. pylori infection frequency (p = 0.37). Asymptomatic H. pylori infection rate was not significantly different between NAFLD patients and control subjects in Birjand, Iran.
format Online
Article
Text
id pubmed-6685302
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Carol Davila University Press
record_format MEDLINE/PubMed
spelling pubmed-66853022019-08-12 Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran Mohammadifard, Mahyar Saremi, Zeinab Rastgoo, Mahboobe Akbari, Ehsan J Med Life Original Article There is evidence that infection by H. pylori can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the toxic products of the bacterium H. pylori and oxidative injury for hepatocytes which promotes hepatic injury. The present research was aimed at determining the association between H. pylori infection and the prevalence of NAFLD in Birjand, Iran. Two groups were included in this cross-sectional study at the outpatient university clinic. One group had NAFLD (65 patients) and the other group was healthy controls without NAFLD (65 subjects). The diagnosis of NAFLD was performed using abdominal ultrasound examination and the absence of taking steatogenic medications or alcohol. Serum anti-H. pylori IgG and fecal H. pylori antigen were tested for diagnosing of H. pylori infection using ELISA method. H. pylori infection diagnosis was made if both tests were positive. None of the subjects in either group had symptoms related to the digestive system including dyspepsia, GERD (gastroesophageal reflux disease), or epigastric pain suspicious of peptic ulcer disease. There were 37 patients (28.5%) in both NAFLD (22 cases, 33.8%) and control (15 cases, 23.1%) groups whose H. pylori tests (both IgG and fecal antigen) were positive. Statistically, no significant difference was observed between the two studied groups regarding H. pylori infection frequency (p = 0.37). Asymptomatic H. pylori infection rate was not significantly different between NAFLD patients and control subjects in Birjand, Iran. Carol Davila University Press 2019 /pmc/articles/PMC6685302/ /pubmed/31406519 http://dx.doi.org/10.25122/jml-2019-0012 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Mohammadifard, Mahyar
Saremi, Zeinab
Rastgoo, Mahboobe
Akbari, Ehsan
Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran
title Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran
title_full Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran
title_fullStr Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran
title_full_unstemmed Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran
title_short Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran
title_sort relevance between helicobacter pylori infection and non-alcoholic fatty liver disease in birjand, iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685302/
https://www.ncbi.nlm.nih.gov/pubmed/31406519
http://dx.doi.org/10.25122/jml-2019-0012
work_keys_str_mv AT mohammadifardmahyar relevancebetweenhelicobacterpyloriinfectionandnonalcoholicfattyliverdiseaseinbirjandiran
AT saremizeinab relevancebetweenhelicobacterpyloriinfectionandnonalcoholicfattyliverdiseaseinbirjandiran
AT rastgoomahboobe relevancebetweenhelicobacterpyloriinfectionandnonalcoholicfattyliverdiseaseinbirjandiran
AT akbariehsan relevancebetweenhelicobacterpyloriinfectionandnonalcoholicfattyliverdiseaseinbirjandiran