Loss of ICP22 in HSV-1 Elicits Immune Infiltration and Maintains Stromal Keratitis Despite Reduced Primary and Latent Virus Infectivity

PURPOSE: We previously have reported that ICP22, an immediate early gene of herpes simplex virus type 1 (HSV-1), binds to the CD80 promoter to suppress CD80 expression in antigen-presenting cells, leading to reduced T-cell function and protection. In contrast, overexpression of CD80 exacerbates corn...

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Detalles Bibliográficos
Autores principales: Matundan, Harry H., Jaggi, Ujjaldeep, Wang, Shaohui, Ghiasi, Homayon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Immunology and Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685448/
https://www.ncbi.nlm.nih.gov/pubmed/31387116
http://dx.doi.org/10.1167/iovs.19-27701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685448/
https://www.ncbi.nlm.nih.gov/pubmed/31387116
http://dx.doi.org/10.1167/iovs.19-27701

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