DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth

Neutrophil extracellular trap (NET) formation results in the expulsion of granulocyte proteins and DNA into the extracellular space. This process is mediated by the enzyme peptidyl arginine deiminase 4 (PADI4) and translocation of elastase to the nucleus. NET formation, marked by increased levels of...

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Detalles Bibliográficos
Autores principales: Miller-Ocuin, Jennifer L., Liang, Xiaoyan, Boone, Brian A., Doerfler, W. Reed, Singhi, Aatur D., Tang, Daolin, Kang, Rui, Lotze, Michael T., Zeh, Herbert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685506/
https://www.ncbi.nlm.nih.gov/pubmed/31428515
http://dx.doi.org/10.1080/2162402X.2019.1605822

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