Bcl11b prevents fatal autoimmunity by promoting T(reg) cell program and constraining innate lineages in T(reg) cells

Regulatory T (T(reg)) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the T(reg) cell program. We found that mice deficient in Bcl11b TF solely in T(reg) cells developed fatal autoimmun...

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Detalles Bibliográficos
Autores principales: Drashansky, Theodore T., Helm, Eric, Huo, Zhiguang, Curkovic, Nina, Kumar, Preet, Luo, Xiaoping, Parthasarathy, Upasana, Zuniga, Ashley, Cho, Jonathan J., Lorentsen, Kyle J., Xu, Zhiwei, Uddin, Mohammad, Moshkani, Safiehkhathoon, Zhou, Liang, Avram, Dorina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685710/
https://www.ncbi.nlm.nih.gov/pubmed/31457080
http://dx.doi.org/10.1126/sciadv.aaw0480

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