Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1

Ras-related C3 botulinum toxin substrate 1 (Rac1) functions as a molecular switch by cycling between an inactive guanosine diphosphate (GDP)–bound state and an active guanosine triphosphate (GTP)–bound state. An oncogenic mutant of Rac1, an N92I mutant, strongly promotes cell proliferation and subse...

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Detalles Bibliográficos
Autores principales: Toyama, Yuki, Kontani, Kenji, Katada, Toshiaki, Shimada, Ichio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685717/
https://www.ncbi.nlm.nih.gov/pubmed/31457101
http://dx.doi.org/10.1126/sciadv.aax1595

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