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Full recovery of the Alzheimer’s disease phenotype by gain of function of Vacuolar Protein Sorting 35
Deficit in retromer complex function secondary to lower levels of one of its major components, the vacuolar protein sorting 35 (VPS35), has been reported in Alzheimer’s disease (AD) brains. VPS35 genetic reduction results in increased Aβ levels and synaptic pathology in mouse models of the disease....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685773/ https://www.ncbi.nlm.nih.gov/pubmed/30733594 http://dx.doi.org/10.1038/s41380-019-0364-x |