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The protective and pathogenic roles of IL-17 in viral infections: friend or foe?
Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication. However, proinflammatory antiviral immune responses pos...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685926/ https://www.ncbi.nlm.nih.gov/pubmed/31337278 http://dx.doi.org/10.1098/rsob.190109 |
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author | Ma, Wen-Tao Yao, Xiao-Ting Peng, Qun Chen, De-Kun |
author_facet | Ma, Wen-Tao Yao, Xiao-Ting Peng, Qun Chen, De-Kun |
author_sort | Ma, Wen-Tao |
collection | PubMed |
description | Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication. However, proinflammatory antiviral immune responses pose a great threat to the host if not properly held in check. Interleukin (IL)-17 is a pleiotropic cytokine participating in a variety of physiological and pathophysiological conditions, including tissue integrity maintenance, cancer progression, autoimmune disease development and, more intriguingly, infectious diseases. Abundant evidence suggests that while IL-17 plays a crucial role in enhancing effective antiviral immune responses, it may also promote and exacerbate virus-induced illnesses. Accumulated experimental and clinical evidence has broadened our understanding of the seemingly paradoxical role of IL-17 in viral infections and suggests that IL-17-targeted immunotherapy may be a promising therapeutic option. Herein, we summarize current knowledge regarding the protective and pathogenic roles of IL-17 in viral infections, with emphasis on underlying mechanisms. The various and critical roles of IL-17 in viral infections necessitate the development of therapeutic strategies that are uniquely tailored to both the infectious agent and the infection environment. |
format | Online Article Text |
id | pubmed-6685926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-66859262019-08-09 The protective and pathogenic roles of IL-17 in viral infections: friend or foe? Ma, Wen-Tao Yao, Xiao-Ting Peng, Qun Chen, De-Kun Open Biol Review Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication. However, proinflammatory antiviral immune responses pose a great threat to the host if not properly held in check. Interleukin (IL)-17 is a pleiotropic cytokine participating in a variety of physiological and pathophysiological conditions, including tissue integrity maintenance, cancer progression, autoimmune disease development and, more intriguingly, infectious diseases. Abundant evidence suggests that while IL-17 plays a crucial role in enhancing effective antiviral immune responses, it may also promote and exacerbate virus-induced illnesses. Accumulated experimental and clinical evidence has broadened our understanding of the seemingly paradoxical role of IL-17 in viral infections and suggests that IL-17-targeted immunotherapy may be a promising therapeutic option. Herein, we summarize current knowledge regarding the protective and pathogenic roles of IL-17 in viral infections, with emphasis on underlying mechanisms. The various and critical roles of IL-17 in viral infections necessitate the development of therapeutic strategies that are uniquely tailored to both the infectious agent and the infection environment. The Royal Society 2019-07-24 /pmc/articles/PMC6685926/ /pubmed/31337278 http://dx.doi.org/10.1098/rsob.190109 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Ma, Wen-Tao Yao, Xiao-Ting Peng, Qun Chen, De-Kun The protective and pathogenic roles of IL-17 in viral infections: friend or foe? |
title | The protective and pathogenic roles of IL-17 in viral infections: friend or foe? |
title_full | The protective and pathogenic roles of IL-17 in viral infections: friend or foe? |
title_fullStr | The protective and pathogenic roles of IL-17 in viral infections: friend or foe? |
title_full_unstemmed | The protective and pathogenic roles of IL-17 in viral infections: friend or foe? |
title_short | The protective and pathogenic roles of IL-17 in viral infections: friend or foe? |
title_sort | protective and pathogenic roles of il-17 in viral infections: friend or foe? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685926/ https://www.ncbi.nlm.nih.gov/pubmed/31337278 http://dx.doi.org/10.1098/rsob.190109 |
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