Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors

Osteosarcoma (OS) represents 3.4% of all childhood cancers with overall survival of 70% not improving in 30 years. The consistent surface overexpression of insulin-like growth factor-2 receptor (IGF2R) has been reported in commercial and patient-derived xenograft (PDX) OS cell lines. We aimed to ass...

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Detalles Bibliográficos
Autores principales: Karkare, Sharayu, Allen, Kevin J. H., Jiao, Rubin, Malo, Mackenzie E., Dawicki, Wojciech, Helal, Muath, Godson, Dale L., Dickinson, Ryan, MacDonald-Dickinson, Valerie, Yang, Rui, Hoang, Bang, Gorlick, Richard, Geller, David S., Dadachova, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685985/
https://www.ncbi.nlm.nih.gov/pubmed/31391495
http://dx.doi.org/10.1038/s41598-019-47808-y

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