ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when combined with PI3K activation. Sorted mutant epithelial cells di...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilson, Mike R., Reske, Jake J., Holladay, Jeanne, Wilber, Genna E., Rhodes, Mary, Koeman, Julie, Adams, Marie, Johnson, Ben, Su, Ren-Wei, Joshi, Niraj R., Patterson, Amanda L., Shen, Hui, Leach, Richard E., Teixeira, Jose M., Fazleabas, Asgerally T., Chandler, Ronald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686004/
https://www.ncbi.nlm.nih.gov/pubmed/31391455
http://dx.doi.org/10.1038/s41467-019-11403-6

Ejemplares similares

Ejemplares similares