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Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells

Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)(2)(PPh(3))(2)] (1) and [Ru(6m2tu)(2)(dppb)] (2) (where PPh(3 = )triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study wa...

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Detalles Bibliográficos
Autores principales:	Bomfim, Larissa M., de Araujo, Fênix A., Dias, Rosane B., Sales, Caroline B. S., Rocha, Clarissa A. Gurgel, Correa, Rodrigo S., Soares, Milena B. P., Batista, Alzir A., Bezerra, Daniel P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686011/ https://www.ncbi.nlm.nih.gov/pubmed/31391500 http://dx.doi.org/10.1038/s41598-019-47914-x

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