A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases

Proteases are one of attractive therapeutic targets to play key roles in pharmacological action. There are many protease inhibitors in nature, and most of them structurally have cystine knot motifs. Their structures are favorable for recognition of active pockets of proteases, leading to the potent...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishimiya, Daisuke, Kawaguchi, Yoshirou, Kodama, Shiho, Nasu, Hatsumi, Yano, Hidenori, Yamaguchi, Aya, Tamura, Masakazu, Hashimoto, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686015/
https://www.ncbi.nlm.nih.gov/pubmed/31391482
http://dx.doi.org/10.1038/s41598-019-47615-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686015/
https://www.ncbi.nlm.nih.gov/pubmed/31391482
http://dx.doi.org/10.1038/s41598-019-47615-5

Ejemplares similares