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A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases
Proteases are one of attractive therapeutic targets to play key roles in pharmacological action. There are many protease inhibitors in nature, and most of them structurally have cystine knot motifs. Their structures are favorable for recognition of active pockets of proteases, leading to the potent...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686015/ https://www.ncbi.nlm.nih.gov/pubmed/31391482 http://dx.doi.org/10.1038/s41598-019-47615-5 |