Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis

Blood-brain barrier (BBB) breakdown is a hallmark of many diseases of the central nervous system (CNS). Loss of BBB integrity in CNS diseases such as viral encephalitis results in the loss of nutrient/oxygen delivery, rapid infiltration of immune cells, and brain swelling that can exacerbate neurona...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonney, Stephanie, Seitz, Scott, Ryan, Caitlin A., Jones, Kenneth L., Clarke, Penny, Tyler, Kenneth L., Siegenthaler, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686045/
https://www.ncbi.nlm.nih.gov/pubmed/31387911
http://dx.doi.org/10.1128/mBio.01675-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686045/
https://www.ncbi.nlm.nih.gov/pubmed/31387911
http://dx.doi.org/10.1128/mBio.01675-19

Ejemplares similares